Binding of oestradiol to blood proteins and aetiology of breast cancer

Binding of oestradiol to blood proteins and aetiology of breast cancer
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雌二醇与血液蛋白的结合和乳腺癌的病因学

DOI:
--
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发表时间:
1986
影响因子:
6.4
通讯作者:
R. Bulbrook
R. Bulbrook
中科院分区:
医学1区
文献类型:
--
作者:
J. Moore;G. Clark;S. Hoare;R. Millis;J. Hayward;M. Quinlan;Dennis Y. Wang;R. Bulbrook

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一项针对 5,000 名女性的前瞻性研究表明,与对照组相比,后来患上乳腺癌的女性血液中非蛋白质结合和白蛋白结合部分(生物可利用部分)中雌二醇的比例较高,而性激素结合部分中的比例较低。生物可利用雌二醇比例的增加部分是由于性激素结合球蛋白浓度较低。体重作为混杂因素被排除在外。
A prospective study of 5,000 women has shown that, compared to controls, those who subsequently developed breast cancer had a higher proportion of their blood oestradiol in the non‐protein‐bound and albumin‐bound fractions (the bio‐available fraction) and a lower proportion in the sex‐hormone‐bound fraction. The increased proportion of bio‐available oestradiol was partly due to a lower concentration of sex‐hormone‐binding globulin. Weight was excluded as a confounding factor.
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影响因子: --
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DOI: --
发表时间: 1982
影响因子: 7.2
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