Naturalistic Audio-Movies reveal common spatial organization across “visual” cortices of different blind individuals
Naturalistic Audio-Movies reveal common spatial organization across “visual” cortices of different blind individuals
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自然主义的音频电影揭示了不同盲人“视觉”皮层的共同空间组织
DOI：
10.1093/cercor/bhac048
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Bedny, Marina
中科院分区：
文献类型：
--
作者：
Musz, Elizabeth;Loiotile, Rita;Chen, Janice;Bedny, Marina
不同视力的人的枕叶皮质包含类似的视觉信息图（例如中央凹与周边）。在先天性失明中，“视觉”皮层会对非视觉刺激做出反应。不同盲人的视觉皮层是否代表共同的信息图？我们利用自然刺激和主体间模式相似性分析来解决这个问题。蒙眼视力正常 (n= 22) 和先天性失明 (n= 22) 参与者聆听 6 个声音片段（每个 5-7 分钟）：3 个电影听觉摘录；自然主义的口语叙述；并在功能磁共振成像扫描期间匹配退化的听觉刺激（向后言语、乱序句子）。我们比较了盲人和视力正常的人不同听觉摘录的每个独特的 10 秒片段所引发的空间活动模式。有意义的自然刺激片段在额颞叶网络中产生了独特的活动模式，这些模式在盲人和视力正常的个体之间共享。仅在盲人组中，视觉皮层中出现了特定片段的跨主题模式，但仅限于有意义的自然刺激，而不是倒向言语。视觉皮层内的活动空间模式对有意义的自然听觉刺激中的时变信息敏感，盲人的情况大致相似。
Occipital cortices of different sighted people contain analogous maps of visual information (e.g. foveal vs. peripheral). In congenital blindness, “visual” cortices respond to nonvisual stimuli. Do visual cortices of different blind people represent common informational maps? We leverage naturalistic stimuli and inter-subject pattern similarity analysis to address this question. Blindfolded sighted (n= 22) and congenitally blind (n= 22) participants listened to 6 sound clips (5–7 min each): 3 auditory excerpts from movies; a naturalistic spoken narrative; and matched degraded auditory stimuli (Backwards Speech, scrambled sentences), during functional magnetic resonance imaging scanning. We compared the spatial activity patterns evoked by each unique 10-s segment of the different auditory excerpts across blind and sighted people. Segments of meaningful naturalistic stimuli produced distinctive activity patterns in frontotemporal networks that were shared across blind and across sighted individuals. In the blind group only, segment-specific, cross-subject patterns emerged in visual cortex, but only for meaningful naturalistic stimuli and not Backwards Speech. Spatial patterns of activity within visual cortices are sensitive to time-varying information in meaningful naturalistic auditory stimuli in a broadly similar manner across blind individuals.