Coated polymeric needles for rapid and deep intradermal delivery
Coated polymeric needles for rapid and deep intradermal delivery
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DOI：
10.1016/j.ijpx.2020.100048
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发表时间：
2020-12-01
影响因子：
4.7
通讯作者：
Donnelly, Ryan F.
中科院分区：
文献类型：
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作者：
Carcamo-Martinez, Alvaro;Anjani, Qonita Kurnia;Donnelly, Ryan F.
制造两组不同长度（2 mm和4.5 mm）的具有限定基部宽度的单个聚合物针（交联的Gantrez S-97和聚乙二醇），并使用两种皮肤模型（Parafilm和猪皮）测试它们的机械强度和插入能力。对于较短的针，施加轴向力（32 N）导致高度降低约80%。尽管如此，在两种皮肤模型中成功插入了约80%的总针长度。光学相干断层扫描显示，基部宽度高度影响较长针的插入能力，因为只有较厚的针（基部宽度为0.922 mm）插入到猪皮中。此外，将针用罗丹明B涂覆并插入猪皮中。与对照相比，模型药物的穿透深度对于短针分别增加2倍，对于长针分别增加4.5倍。此外，通过皮肤切片的定量显示，较短的针在1.5-2.0 mm的深度递送10 μ g的化合物，而长针能够将5 μ g递送到甚至更深的皮肤层（2.0-3.0 mm）中，证实了涂覆的聚合物针用于快速和深层皮内递送的潜力。
Two groups of single polymeric needles (crosslinked Gantrez (R) S-97 and poly(ethylene glycol)) of different lengths (2 mm and 4.5 mm) with defined base widths were fabricated and tested in terms of their mechanical strength and insertion abilities using two skin models (Parafilm (R) and porcine skin). For the shorter needles, application of an axial force (32 N) resulted in a height reduction of approximately 80%. Nonetheless, around 80% of total needle length was successfully inserted in both skin models. Optical coherence tomography showed that base width highly impacted insertion capabilities of the longer needles as only the thicker one (0.922 mm width at base) inserted into porcine skin. Additionally, needles were coated with rhodamine B and inserted into porcine skin. In comparison to a control, penetration depth of the model drug increased 2-fold for short and 4.5-fold for long needles, respectively. Moreover, quantification across skin sections showed that shorter needles delivered 10 mu g of the compound in a depth of 1.5-2.0 mm while long needles were capable of delivering 5 mu g into even deeper skin layers (2.0-3.0 mm), confirming the potential of coated polymeric needles for rapid and deep intradermal delivery.