Lipid and polymeric carrier-mediated nucleic acid delivery.
Lipid and polymeric carrier-mediated nucleic acid delivery.
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DOI：
10.1517/17425247.2010.513969
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发表时间：
2010-10
影响因子：
6.6
通讯作者：
Mahato RI
中科院分区：
文献类型：
--
作者：
Zhu L;Mahato RI
核酸，如质粒DNA、反义寡核苷酸和RNA干扰(RNAi)分子，在治疗各种遗传和获得性疾病方面具有巨大的潜力。为了设计一个成功的核酸递送系统，必须对核酸的药理作用、受试者或部位的生理状况以及核酸和载体的物理化学性质进行彻底的检测。综述了常用的脂类、聚合物和相应的给药系统的特点、应用、优点和局限性。本文旨在提供生物障碍的概述和通过适当设计有效的合成载体来克服这些障碍的策略。深入了解生物屏障以及脂质和聚合物载体的构效关系是有效的核酸治疗的关键。
Nucleic acids such as plasmid DNA, antisense oligonucleotide, and RNA interference (RNAi) molecules, have a great potential to be used as therapeutics for the treatment of various genetic and acquired diseases. To design a successful nucleic acid delivery system, the pharmacological effect of nucleic acids, the physiological condition of the subjects or sites, and the physicochemical properties of nucleic acid and carriers have to be thoroughly examined. The commonly used lipids, polymers and corresponding delivery systems are reviewed in terms of their characteristics, applications, advantages and limitations. This article aims to provide an overview of biological barriers and strategies to overcome these barriers by properly designing effective synthetic carriers for nucleic acid delivery. A thorough understanding of biological barriers and the structure–activity relationship of lipid and polymeric carriers is the key for effective nucleic acid therapy.
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DOI：
10.1124/jpet.105.100347
发表时间：
2006-05-01
影响因子：
3.5
作者：
Cheng, K;Ye, ZY;Mahato, RI
通讯作者：
Mahato, RI
影响因子：
4.7
作者：
Derfus, Austin M.;Chen, Alice A.;Bhatia, Sangeeta N.
通讯作者：
Bhatia, Sangeeta N.
影响因子：
4.7
作者：
Gaucheron, J;Wong, T;Cullis, PR
通讯作者：
Cullis, PR
影响因子：
2.9
作者：
Aberle, AM;Tablin, F;Nantz, MH
通讯作者：
Nantz, MH
影响因子：
3.8
作者：
Braun, CS;Vetro, JA;Middaugh, CR
通讯作者：
Middaugh, CR