Development of an AIDS vaccine using Sendai virus vectors
Development of an AIDS vaccine using Sendai virus vectors
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DOI：
10.1016/j.vaccine.2015.06.114
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发表时间：
2015-11-09
期刊：
影响因子：
5.5
通讯作者：
Matano, Tetsuro
中科院分区：
文献类型：
--
作者：
Ishii, Hiroshi;Matano, Tetsuro
开发有效的艾滋病疫苗对于控制全球人类免疫缺陷病毒1型（HIV-1）的流行至关重要。我们利用仙台病毒（SeV）载体研制了一种新型艾滋病疫苗，并在猴免疫缺陷病毒（SIV）感染的猕猴艾滋病模型上研究了疫苗的有效性。其免疫原性和保护作用已被证实，表明SeV载体是一种很有前景的艾滋病疫苗递送工具。在这里，我们描述了SeV载体作为疫苗抗原递送工具的潜力，以诱导针对HIV-1感染的有效免疫反应。(C) 2015 Elsevier Ltd.版权所有。
Development of an effective AIDS vaccine is crucial for the control of global human immunodeficiency virus type 1 (HIV-1) prevalence. We have developed a novel AIDS vaccine using a Sendai virus (SeV) vector and investigated its efficacy in a macaque AIDS model of simian immunodeficiency virus (SIV) infection. Its immunogenicity and protective efficacy have been shown, indicating that the SeV vector is a promising delivery tool for AIDS vaccines. Here, we describe the potential of SeV vector as a vaccine antigen delivery tool to induce effective immune responses against HIV-1 infection. (C) 2015 Elsevier Ltd. All rights reserved.