ROD OUTER SEGMENT DISK SHEDDING IN RAT RETINA - RELATIONSHIP TO CYCLIC LIGHTING
ROD OUTER SEGMENT DISK SHEDDING IN RAT RETINA - RELATIONSHIP TO CYCLIC LIGHTING
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DOI：
10.1126/science.982063
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发表时间：
1976-01-01
期刊：
影响因子：
56.9
通讯作者：
LAVAIL, MM
中科院分区：
文献类型：
--
作者：
LAVAIL, MM
白化大鼠在周期性光照下饲养时，视网膜在光照后不久就会出现视杆外节视盘的突然脱落。此时色素上皮中大包的外节圆盘(吞噬小体)的数量比白天或夜晚的任何时候都多2.5-5倍。随后，色素上皮细胞内的大吞噬小体迅速降解为较小的结构。盘脱落的爆发遵循昼夜节律，至少持续3天，因为它同时发生在连续的黑暗中，而不是光的开始。
When albino rats are reared in cyclic light, a burst of rod outer segment disk shedding occurs in the retina soon after the onset of light. The number of large packets of outer segment disks (phagosomes) in the pigment epithelium at this time is 2.5-5 times greater than at any other time of day or night. The subsequent degradation of large phagosomes to smaller structures within pigment epithelial cells proceeds rapidly. The burst of disk shedding follows a circadian rhythm for at least 3 days, since it occurs in continuous darkness at the same time without the onset of light.