Cortico-basal white matter alterations occurring in Parkinson's disease
Cortico-basal white matter alterations occurring in Parkinson's disease
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DOI：
10.1371/journal.pone.0214343
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发表时间：
2019-08-19
期刊：
影响因子：
3.7
通讯作者：
Keuken, Max. C.
中科院分区：
文献类型：
--
作者：
Isaacs, Bethany. R.;Trutti, Anne. C.;Keuken, Max. C.
磁共振成像研究通常使用标准解剖图谱来识别和分析对特定大脑区域的（病理）生理影响；这些地图集通常无法纳入因年龄和疾病而可能发生的神经解剖学改变。本研究利用帕金森病和丘脑底核的年龄特异性解剖图谱进行扩散纤维束成像，评估丘脑底核和已知受帕金森病影响的先验定义的皮质区域之间的纤维束。结果表明，白质纤维束的强度在结构上似乎不受疾病的影响。与此相反，帕金森病患者的下丘脑核与额下回岛盖部、前扣带皮层、背外侧前额叶皮层和前辅助运动之间的连接部分各向异性值显示下降，这些区域共同参与准备运动控制、决策和任务监控。虽然分数各向异性改变的生物学基础仍然难以捉摸，但它们仍然可以用作帕金森病的指标。此外，我们发现，未能考虑丘脑底核随年龄和疾病发生的结构变化会降低纤维束成像的准确性并影响其结果，这凸显了使用适当的图谱进行纤维束成像的重要性。
Magnetic resonance imaging studies typically use standard anatomical atlases for identification and analyses of (patho-)physiological effects on specific brain areas; these atlases often fail to incorporate neuroanatomical alterations that may occur with both age and disease. The present study utilizes Parkinson's disease and age-specific anatomical atlases of the subthalamic nucleus for diffusion tractography, assessing tracts that run between the subthalamic nucleus and a-priori defined cortical areas known to be affected by Parkinson's disease. The results show that the strength of white matter fiber tracts appear to remain structurally unaffected by disease. Contrary to that, Fractional Anisotropy values were shown to decrease in Parkinson's disease patients for connections between the subthalamic nucleus and the pars opercularis of the inferior frontal gyrus, anterior cingulate cortex, the dorsolateral prefrontal cortex and the pre-supplementary motor, collectively involved in preparatory motor control, decision making and task monitoring. While the biological underpinnings of fractional anisotropy alterations remain elusive, they may nonetheless be used as an index of Parkinson's disease. Moreover, we find that failing to account for structural changes occurring in the subthalamic nucleus with age and disease reduce the accuracy and influence the results of tractography, highlighting the importance of using appropriate atlases for tractography.