Gentian violet exhibits activity against biofilms formed by oral Candida isolates obtained from HIV-infected patients.
Gentian violet exhibits activity against biofilms formed by oral Candida isolates obtained from HIV-infected patients.
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龙胆紫对从 HIV 感染者的口腔念珠菌分离株形成的生物膜具有活性。
DOI：
10.1128/aac.01601-10
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发表时间：
2011
影响因子：
4.9
通讯作者：
Ghannoum,MahmoudA
中科院分区：
文献类型：
--
作者：
Traboulsi,RanaS;Mukherjee,PranabK;Chandra,Jyotsna;Salata,RobertA;Jurevic,Richard;Ghannoum,MahmoudA
使用干重测定和共聚焦激光扫描显微镜评价龙胆紫对在聚甲基丙烯酸甲酯条上形成的白色念珠菌和非白色念珠菌生物膜的作用。还评估了龙胆紫抑制白色念珠菌萌发的能力。甘精紫对念珠菌属生物膜的活性通过干重的减少、生物膜结构的破坏和生物膜厚度的减少来证明。此外，龙胆紫以浓度依赖性方式抑制念珠菌的萌发。
The effect of gentian violet against Candida albicans and non-Candida albicansbiofilms formed on polymethylmethacrylate strips was evaluated using a dry weight assay and confocal laser scanning microscopy. The ability of gentian violet to inhibit Candida albicans germination was also assessed. Gentian violet activity against Candida biofilms was demonstrated by a reduction in dry weight, disruption of biofilm architecture, and reduced biofilm thickness. Additionally, gentian violet inhibited Candida germination in a concentration-dependent manner.