The effect of nasally administered budesonide respules on adrenal cortex function in patients with chronic rhinosinusitis.
The effect of nasally administered budesonide respules on adrenal cortex function in patients with chronic rhinosinusitis.
复制标题
DOI：
10.1001/archoto.2008.555
复制
发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Vlahiotis A
中科院分区：
文献类型：
--
作者：
Sachanandani NS;Piccirillo JF;Kramper MA;Thawley SE;Vlahiotis A
To evaluate whether nasal administration of budesonide in adults with chronic rhinosinusitis for 30 days suppresses adrenal function and to assess its clinical efficacy. An open-label prospective study. Academic medical center. We assessed adrenal function in 9 patients using the cosyntropin test before and after budesonide therapy. Budesonide respule therapy. Scores from the Sino-Nasal Outcome Test–20 (SNOT-20), a tool for assessing rhinosinusitis health and quality of life, were used to assess efficacy of budesonide treatment. All of our patients showed adequate adrenal response to cosyntropin stimulation before and after the budesonide trial. The mean difference in SNOT-20 scores was −1 (95% confidence interval, −1.77 to −0.23; P=.02), indicating clinically significant improvement after therapy. Our findings suggest that using budesonide nasal wash may be clinically effective in decreasing the symptoms of chronic rhinosinusitis and does so without suppression of the hypothalamic-pituitary-adrenal axis in patients with chronic rhinosinusitis.
登录
查看更多内容
影响因子：
8
作者：
Baker, JW;Mellon, M;Walton-Bowen, K
通讯作者：
Walton-Bowen, K
影响因子：
14.2
作者：
Shapiro, G;Mendelson, L;Smith, JA
通讯作者：
Smith, JA
影响因子：
3.4
作者：
Piccirillo, JF;Merritt, MG;Richards, ML
通讯作者：
Richards, ML
影响因子：
158.5
作者：
Agertoft, L;Pedersen, S
通讯作者：
Pedersen, S
影响因子：
5.9
作者：
Murphy, Kevin;Uryniak, Tom;O'Dowd, Liza
通讯作者：
O'Dowd, Liza