Cholinesterase-inhibiting withanolides from Ajuga bracteosa
Cholinesterase-inhibiting withanolides from Ajuga bracteosa
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DOI：
10.1002/cbdv.200490091
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发表时间：
2004-01-01
影响因子：
2.9
通讯作者：
Choudhary, MI
中科院分区：
文献类型：
--
作者：
Riaz, N;Malik, A;Choudhary, MI
三个新的睡茄内酯，bracteosin A（=（22 R）-5 β，6 β：22，26-二环氧基-4 β，28-二羟基-3 β-甲氧基麦角甾-24-烯-1，26-二酮; 1），bracteosin B（=（22 R）-5 β，6 β：22，26-二环氧基-4 β，28-二羟基-3 β-甲氧基-1，26-二氧麦角甾-24-烯-19-酸; 2），和bracteosin C（=（22 R）-22，26-环氧-4 β，6 β，27-三羟基-3 β-甲氧基麦角甾-24-烯-1，26-二酮; 3）。从大苞筋骨草的全株中分离得到一系列化合物。通过1D-和2D-NMR技术等波谱分析推测了它们的结构。此外，二氢clerodin-1，clerodinA，lupulinA，和二氢ajugapitin也首次从该物种中分离。化合物1-3对胆碱酯酶具有明显的抑制作用，且呈浓度依赖性。
Three new withanolides, bracteosin A (= (22R)-5beta,6beta: 22,26-diepoxy-4beta,28-dihydroxy-3beta-methoxyergost-24-ene-1,26-dione; 1), bracteosin B (= (22R)-5beta,6beta: 22,26-diepoxy-4beta,28-dihydroxy-3beta-methoxy-1,26-dioxoergost-24-en-19-oic acid; 2), and bracteosin C (= (22R)-22,26-epoxy-4beta,6beta,27-trihydroxy-3beta-methoxyergost- 24-ene-1,26-dione; 3). have been isolated from the whole plants of Ajuga bracteosa. Their structures were deduced by spectral analysis, including 1D- and 2D-NMR techniques. In addition, dihydroclerodin-1, clerodinin A, lupulin A, and dihydroajugapitin have also been isolated for the first time from this species. Compounds 1-3 exhibited evident inhibitory potential against cholinesterase enzymes in a concentration-dependent fashion.