ASYMMETRY IN BEHAVIORAL-RESPONSES TO CHOLECYSTOKININ MICROINJECTED INTO RAT NUCLEUS-ACCUMBENS AND AMYGDALA
ASYMMETRY IN BEHAVIORAL-RESPONSES TO CHOLECYSTOKININ MICROINJECTED INTO RAT NUCLEUS-ACCUMBENS AND AMYGDALA
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DOI：
10.1016/0028-3908(94)90158-9
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发表时间：
1994-08-01
影响因子：
4.7
通讯作者：
PETKOV, VD
中科院分区：
文献类型：
--
作者：
BELCHEVA, I;BELCHEVA, S;PETKOV, VD
本文观察了大鼠杏仁核和延髓左侧和/或右侧或双侧微量注射八肽胆囊收缩素（CCK-8）后的行为反应。NA内微量注射CCK-8的效应主要有两个发现。首先，双侧注射CCK-8到NA剂量依赖性地降低水平活动。第二个更重要的发现是，CCK-8在特定剂量（0.01 μ g）注射到右侧NA的水平运动的数量增加了6倍，相比于注射到左侧NA。无论是单，也不是双边注射CCK-8到NA在所有剂量使用引起的垂直运动的变化。在最低剂量（0.01 μ g）时，CCK-8注入左、右或双侧amigdalae可增加运动，而在高剂量（0.5和1.0 μ g）时，CCK-8显著降低运动。CCK-8注射到左侧杏仁核而不是右侧杏仁核时，对学习和记忆（穿梭箱）产生了有利的影响。注射CCK-8（0.01 μ g）到左杏仁核引起的回避的数量增加了4倍相比，微量注射到右杏仁核。
The behavioral responses of rats to uni- or bilateral microinjections of the octapeptide cholecystokinin (CCK-8) into the left and/or right or both nucleus accumbens (NA) or amygdalae were studied. There were two main findings of effects of microinjections of CCK-8 into NA. First, bilateral injections of CCK-8 into NA dose-dependently decreased the horizontal activity. The second more important finding was that CCK-8 at a specific dose (0.01 mu g) injected into the right NA increased the number of horizontal movements 6-fold as compared to the injection into the left NA. Neither uni- nor bilateral injections of CCK-8 into NA at all doses used induced changes in the vertical movements. CCK-8 injected into left, right or both amigdalae increased locomotion at the lowest dose (0.01 mu g), while at the high doses (0.5 and 1.0 mu g) it significantly decreased it. The plus-maze test confirmed the anxiogenic effect of CCK-8 (0.01 mu g) injected into amigdalae. CCK-8 exerted a favorable effect on learning and memory (shuttle-box) when injected into the left but not into the right amygdala. Injection of CCK-8 (0.01 mu g) into left amygdala provoked a 4-fold increase of the number of avoidances as compared to the microinjection into the right amygdala.