RETINAL HEMORRHAGE, A COMMON SIGN OF PROGNOSTIC-SIGNIFICANCE IN CEREBRAL MALARIA
RETINAL HEMORRHAGE, A COMMON SIGN OF PROGNOSTIC-SIGNIFICANCE IN CEREBRAL MALARIA
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DOI：
10.4269/ajtmh.1983.32.911
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发表时间：
1983-01-01
影响因子：
3.3
通讯作者：
KANCHANARANYA, C
中科院分区：
文献类型：
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作者：
LOOAREESUWAN, S;WARRELL, DA;KANCHANARANYA, C
在 144 名严格定义的脑型疟疾患者中，有 21 名患者出现视网膜出血。 17 例为多发性出血，14 例为双侧出血。2 例出现玻璃体下延伸。2 例出现软性渗出物，4 例出现视网膜水肿，1 例出现双侧视乳头水肿。视网膜出血与恶性疟原虫感染严重程度的几个指标显着相关：高寄生虫血症伴裂殖体血症、贫血、血清肌酐升高和血浆抗凝血酶III降低。只有 2 例出血患者同时患有严重贫血和血小板减少。视网膜出血是脑型疟疾中常见的现象，可能是与该病发病机制有关的血管病变的明显证据。
Retinal hemorrhages were seen in 21 patients among a group of 144 with strictly-defined cerebral malaria. Hemorrhages were multiple in 17 cases and bilateral in 14. There was subhyaloid extension in 2. Soft exudates were seen in 2, the retinae were considered edematous in 4 and in 1 there was bilateral papilledema. Retinal hemorrhages were significantly associated with several indices of severity of P. falciparum infection: high parasitemia with schizontemia, anemia, elevated serum creatinine and reduced plasma antithrombin III. Only 2 patients with hemorrhages were both severely anemic and thrombocytopenic. Retinal hemorrhages, a frequent finding in cerebral malaria, may be visible evidence of vascular lesions involved in the pathogenesis of this condition.