Dietary fat, calories, and mammary gland tumorigenesis.
Dietary fat, calories, and mammary gland tumorigenesis.
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膳食脂肪、热量和乳腺肿瘤发生。
DOI：
10.1007/978-1-4684-7953-9_16
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发表时间：
1992
影响因子：
--
通讯作者：
Welsch,CW
中科院分区：
文献类型：
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作者：
Welsch,CW
在实验动物（小鼠和大鼠）中，改变膳食脂肪的水平和/或类型显著影响乳腺肿瘤的发展。这种现象已经在一系列致癌物诱导的、可移植的、“自发的“和转移性的啮齿动物乳腺肿瘤系统中得到证实。本文的目的是回顾和评论饮食脂肪和啮齿动物乳腺肿瘤发生之间的关系。特别是，五个问题进行审查和批评，即，1)脂肪量与啮齿类动物乳腺肿瘤发生，2）脂肪类型与啮齿类动物乳腺肿瘤发生，3）脂肪与啮齿类动物乳腺肿瘤细胞转移，4）脂肪热量与啮齿类动物乳腺肿瘤发生的关系，以及5）脂肪对免疫缺陷小鼠中人乳腺癌移植物发展的影响。虽然膳食脂肪的量和/或类型已被报道影响正常和/或肿瘤前啮齿动物乳腺的发育和/或生长，84，07，138，151 - 156这些关系，虽然重要，将不在本章讨论。膳食脂肪影响啮齿类动物乳腺肿瘤发生的具体机制已在以前的综述中讨论过157 - 162，但不会成为本次交流的主要焦点。本综述中引用的所有膳食脂肪量均以重量百分比表示。术语“乳腺肿瘤发展”或“乳腺肿瘤发生”表示乳腺肿瘤生长、发病率、数量和/或多样性。
In experimental animals (mice and rats), altering the levels and/or types of dietary fat markedly influences the development of mammary tumors. This phenomenon has now been demonstrated in an impressive array of carcinogen-induced,1–106transplantable,107–121“spontaneous”122–139and metastatic140–150experimental rodent mammary tumor systems. The purpose of this communication is to review and critique the relationships between dietary fat and mammary gland tumorigenesis in rodents. In particular, five issues are examined and critiqued, i.e., 1) amount of fat and rodent mammary tumorigenesis, 2) type of fat and rodent mammary tumorigenesis, 3) fat and rodent mammary tumor cell metastasis, 4) the fatcalorie-rodent mammary tumorigenesis relationship, and 5) influence of fat on development of human breast carcinoma transplants in immune-deficient mice. Although the amount and/or type of dietary fat have been reported to influence the development and/or growth of the normal and/or pre-neoplastic rodent mammary gland,84, 07,138,151–156these relationships, albeit important, will not be discussed in this chapter. Specific mechanisms by which dietary fat influences mammary gland tumorigenesis in rodents have been discussed in previous reviews157–162and will not be a major focus of this communication. All amounts of dietary fat cited in this review are expressed as percent by weight. The terms “mammary tumor development” or “mammary tumorigenesis” denote mammary tumor growth, incidence, number, and/or multiplicity.