Experiments on Maternal Transmission of Creutzfeldt-Jakob Disease in Guinea Pigs 1
Experiments on Maternal Transmission of Creutzfeldt-Jakob Disease in Guinea Pigs 1
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豚鼠克雅氏病母传实验1
DOI：
10.3181/00379727-160-40425
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发表时间：
1979
影响因子：
--
通讯作者：
L. Manuelidis
中科院分区：
文献类型：
--
作者：
E. Manuelidis;L. Manuelidis
总结在脑内和腹膜内接种克雅氏剂后的不同时间，在豚鼠所生后代中未观察到克雅氏病的母体传播。后代几乎在整个妊娠期都暴露于母体感染。也没有证据表明感染横向传播给后代。所有接种的父母都死于组织学证实的亚急性海绵状病毒脑病。
Summary No maternal transmission of Creutzfeldt-Jakob disease was observed in offspring born to guinea pigs at various times after intracerebral and intraperitoneal inoculation with the Creutzfeldt-Jakob agent. The offspring were exposed to the maternal infection during virtually the entire period of gestation. There was also no evidence of lateral transmission of the infection to the offspring. All inoculated parents died with histologically verified subacute spongiform virus encephalopathy.