Conjugated bile acids associate with altered rates of glucose and lipid oxidation after Roux-en-Y gastric bypass.
Conjugated bile acids associate with altered rates of glucose and lipid oxidation after Roux-en-Y gastric bypass.
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DOI：
10.1007/s11695-012-0673-5
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发表时间：
2012-09
期刊：
影响因子：
2.9
通讯作者：
Pihlajamaki, Jussi
中科院分区：
文献类型：
--
作者：
Simonen, M.;Dali-Youcef, N.;Kaminska, D.;Venesmaa, S.;Kakela, P.;Paakkonen, M.;Hallikainen, M.;Kolehmainen, M.;Uusitupa, M.;Moilanen, L.;Laakso, M.;Gylling, H.;Patti, M. E.;Auwerx, J.;Pihlajamaki, Jussi
腹腔镜Roux-en-Y胃旁路术（RYGB）诱导比单独减肥更有利的代谢谱。在这项研究中，我们研究了RYGB对血清胆汁酸水平的影响及其与临床结果的关系。我们纳入了30例接受RYGB治疗的肥胖患者（BMI=46.1±5.9 kg/m2）。术前和术后1年进行临床测量和实验室测定。采用酶法测定空腹血清胆汁酸，采用hlpc -串联质谱法测定单个胆汁酸。间接量热法测量了能量消耗和底物氧化的速率。RYGB治疗前后空腹血清总胆汁酸水平升高2倍（术前为3.68±2.03 μmol/l，术后为7.06±9.65 μmol/l, + 92%, p=0.002）。总胆汁酸的增加伴随着共轭胆汁酸的减少，这与葡萄糖氧化减少（r=0.571, p=0.002）和脂质氧化增加（r= - 0.626, p=0.0004）相关。牛磺酸偶联胆汁酸的变化与脂肪组织中DIO2 mRNA表达的改变相关（r= - 0.498, p=0.013），可能将胆汁酸偶联与通过DIO2氧化底物联系起来。RYGB后空腹血清胆汁酸水平升高。更具体地说，RYGB后胆汁酸偶联的改变与能量代谢的改变有关。
Laparoscopic Roux-en-Y gastric bypass (RYGB) induces a more favorable metabolic profile than expected by weight loss alone. In this study, we investigated the effect of RYGB on serum bile acid levels and their relation to clinical outcomes. We included 30 obese patients who underwent RYGB (BMI=46.1±5.9 kg/m2). Clinical measurements and laboratory determinations were performed before surgery and 1 year after surgery. Fasting serum bile acids were measured by an enzymatic method and individual bile acids were quantified by HLPC-tandem mass spectrometry. Indirect calorimetry was performed to measure the rates of energy expenditure and substrate oxidation. Fasting total serum bile acid levels increased twofold after RYGB (pre, 3.68±2.03 vs. post, 7.06± 9.65 μmol/l, +92 %, p=0.002). This increase in total bile acids was accompanied by a decrease in conjugated bile acids, which correlated with decreased glucose oxidation (r=0.571, p=0.002) and with increased lipid oxidation (r=−0.626, p=0.0004). The change in taurineconjugated bile acids correlated with altered DIO2 mRNA expression in adipose tissue (r=−0.498, p=0.013) potentially linking bile acid conjugation to substrate oxidation through DIO2. Fasting serum bile acid levels increase after RYGB. More specifically, changes in bile acid conjugation after RYGB associate with altered energy metabolism.
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DOI：
10.1038/oby.2009.102
发表时间：
2009-09
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Patti ME;Houten SM;Bianco AC;Bernier R;Larsen PR;Holst JJ;Badman MK;Maratos-Flier E;Mun EC;Pihlajamaki J;Auwerx J;Goldfine AB
通讯作者：
Goldfine AB
影响因子：
15.9
作者：
Watanabe, M;Houten, SM;Auwerx, J
通讯作者：
Auwerx, J
DOI：
10.1016/j.bbrc.2005.01.139
发表时间：
2005-04-01
影响因子：
3.1
作者：
Katsuma, S;Hirasawa, A;Tsujimoto, G
通讯作者：
Tsujimoto, G
影响因子：
158.5
作者：
Sjöström, L;Lindroos, AK;Wedel, H
通讯作者：
Wedel, H
影响因子：
9
作者：
le Roux, Carel W.;Welbourn, Richard;Olbers, Torsten
通讯作者：
Olbers, Torsten