A new sesquiterpene ester from Celastrus orbiculatus reversing multidrug resistance in cancer gels
A new sesquiterpene ester from Celastrus orbiculatus reversing multidrug resistance in cancer gels
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DOI：
10.1021/np9702392
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发表时间：
1998-01-01
影响因子：
5.1
通讯作者：
Kim, YC
中科院分区：
文献类型：
--
作者：
Kim, SE;Kim, YH;Kim, YC
在寻找癌细胞多药耐药回复突变体的过程中，从南蛇藤（Celastrus orbiculatus）的根中分离到一种新的（1）和两种已知的（2，3）倍半萜酯。1的结构被鉴定为1 β，2 β-二乙酰氧基-6 α，9 α-双（苯甲酰氧基）二氢-β-沉香呋喃。化合物1-3部分或完全逆转多药耐药KB-V1和MCF 7/ADR细胞对阿霉素、长春碱和紫杉醇的耐药性。
In a search for revertants of multidrug-resistance in cancer cells, a novel (1) and two known (2, 3) sesquiterpene esters were isolated from the root of Celastrus orbiculatus. The structure of 1 was elucidated as 1 beta,2 beta-diacetoxy-6 alpha,9 alpha-bis(benzoyloxy)dihydro-beta-agarofuran. Compounds 1-3 partially or completely reversed resistance to adriamycin, vinblastine, and paclitaxel of multidrug-resistant KB-V1 and MCF7/ADR cells.