Genetic influences on mosquito feeding behavior and the emergence of zoonotic pathogens
Genetic influences on mosquito feeding behavior and the emergence of zoonotic pathogens
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DOI：
10.4269/ajtmh.2007.77.667
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发表时间：
2007-10-01
影响因子：
3.3
通讯作者：
Fonseca, Dina M.
中科院分区：
文献类型：
--
作者：
Kilpatrick, A. Marm;Kramer, Laura D.;Fonseca, Dina M.
病媒的取食行为影响病原体入侵的可能性和人类对病媒传播的人畜共患病病原体的暴露。我们使用多位点微卫星遗传分型引进蚊子载体和蚊子血粉的DNA测序，以确定混合血统对喂养行为和西尼罗河病毒（WNV）的出现的影响。尖音库蚊的祖先从两个bionomically不同的形式，形式骚扰和形式pipiens的概率，影响的概率，他们对人类的喂养，但并没有解释夏末喂养从鸟类到人类的转变。我们使用了一个简单的模型来表明，纯形式的骚扰蚊子的发生将使WNV入侵的可能性（鸟类种群中的R-0）降低3至8倍，而纯形式的尖音蚊子的发生将使人类暴露量减半。数据和模型表明，喂养偏好可能受到遗传祖先的影响，并有助于出现由引进物种传播的病媒病原体，包括疟疾，登革热，基孔肯雅热，黄热病和西尼罗河病毒。
The feeding behavior of vectors influences the likelihood of pathogen invasion and the exposure of humans to vector-borne zoonotic pathogens. We used multilocus microsatellite genetic typing of an introduced mosquito vector and DNA sequencing of mosquito blood meals to determine the impact of hybrid ancestry on feeding behavior and the emergence of West Nile virus (WNV). The probability of ancestry of Culex pipiens mosquitoes from two bionomically divergent forms, form molestus and form pipiens, influenced the probability that they fed on humans but did not explain a late summer feeding shift from birds to humans. We used a simple model to show that the occurrence of pure form molestus mosquitoes would have decreased the likelihood of WNV invasion (R-0 in bird populations) 3- to 8-fold, whereas the occurrence of pure forms pipiens mosquitoes would have halved human exposure compared with the hybrids that are present. Data and modeling suggest that feeding preferences may be influenced by genetic ancestry and contribute to the emergence of vector-borne pathogens transmitted by introduced species, including malaria, and dengue, Chikungunya, yellow fever, and West Nile viruses.