Effects of Familiarity on Neural Activity in Monkey Inferior Temporal Lobe
Effects of Familiarity on Neural Activity in Monkey Inferior Temporal Lobe
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DOI：
10.1093/cercor/bhn015
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发表时间：
2008-11-01
期刊：
影响因子：
3.7
通讯作者：
Sheinberg, David
中科院分区：
文献类型：
--
作者：
Anderson, Britt;Mruczek, Ryan E. B.;Sheinberg, David
长期的熟悉有助于视觉刺激的识别。为了更好地理解这种效应的神经基础，我们测量了局部场电位（LFP）和多单位尖峰活动（MUA）从下颞叶（IT）的行为猴子在响应新的和熟悉的图像。在一般情况下，熟悉的图像引起较大幅度的LFP，而MUA反应更大的新的图像。熟悉的影响衰减图像旋转45度的图片平面。与熟悉的图像相比，降低图像对比度导致新的LFP响应幅度更明显地降低，并且导致熟悉图像的更有选择性的MUA响应曲线。单个LFP迹线的形状可以用于刺激分类，并且对于熟悉的图像类别，分类性能更好。记录的视觉和听觉诱发LFP在多个深度的LFP形态与距离的变化为2毫米的显着改变。总之，IT皮层显示熟悉和新的图像在时间尺度上的本地处理差异，并在所观察到的行为优势进行分类熟悉的图像和快速检测新的刺激相一致的方式。
Long-term familiarity facilitates recognition of visual stimuli. To better understand the neural basis for this effect, we measured the local field potential (LFP) and multiunit spiking activity (MUA) from the inferior temporal (IT) lobe of behaving monkeys in response to novel and familiar images. In general, familiar images evoked larger amplitude LFPs whereas MUA responses were greater for novel images. Familiarity effects were attenuated by image rotations in the picture plane of 45 degrees. Decreasing image contrast led to more pronounced decreases in LFP response magnitude for novel, compared with familiar images, and resulted in more selective MUA response profiles for familiar images. The shape of individual LFP traces could be used for stimulus classification, and classification performance was better for the familiar image category. Recording the visual and auditory evoked LFP at multiple depths showed significant alterations in LFP morphology with distance changes of 2 mm. In summary, IT cortex shows local processing differences for familiar and novel images at a time scale and in a manner consistent with the observed behavioral advantage for classifying familiar images and rapidly detecting novel stimuli.