Monocyte chemotactic protein-1 is increased in the amnioticfluid of women who deliver preterm in the presence or absence of intra-amniotic infection
Monocyte chemotactic protein-1 is increased in the amnioticfluid of women who deliver preterm in the presence or absence of intra-amniotic infection
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DOI：
10.1080/14767050500141329
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发表时间：
2005-06-01
影响因子：
1.8
通讯作者：
Adashi, EY
中科院分区：
文献类型：
--
作者：
Esplin, MS;Romero, R;Adashi, EY
目标。促炎趋化因子与早产有关。单核细胞趋化蛋白-1(MCP-1)是一种趋化因子，能够将单核/巨噬细胞募集到炎症部位，并刺激巨噬细胞激活所需的呼吸爆发。子宫组织(即蜕膜细胞和子宫肌层)表达MCP-1转录本和免疫反应性，因此可能参与分娩过程。本研究旨在确定早产导致早产和羊膜内感染(IAI)是否与MCP-1羊水浓度的变化有关。一项横断面研究旨在检测两组孕妇羊水中MCP-1的浓度：1)胎膜完好者早产；2)胎膜早破(PROM)者。对131例胎膜完整的早产孕妇和105例早产胎膜早破孕妇进行经腹羊水穿刺术获取羊水。羊水微生物培养阳性定义为IAI。第一组包括早产且胎膜完整的妇女(n=131)，分为以下几组：a)无IAI的足月分娩(n=42)；b)无IAI的早产(537周)(n=58)；c)有IAI的早产(n=31)。第2组为胎膜早破组(n=105)，分为胎膜早破组(n=51)和非胎膜早破组(n=54)。采用非参数统计方法进行数据分析。1)在所有羊水样本中均检测到免疫反应性MCP-1；2)无论胎膜状态如何，IAI与免疫反应性MCP-1的羊水中位数浓度显著高于未检测到IAI的羊水中位数(p
Objective. Pro-inflammatory chemokines have been associated with preterm parturition. Monocyte chemotactic protein-1 (MCP-1) is a chemokine capable of recruiting monocytes/macrophages into sites of inflammation, as well as stimulating the respiratory burst required for macrophage activation. MCP-1 transcripts and immuno-reactivity are expressed by uterine tissues (i.e., decidual cells and myometrium) and, thus, may participate in the process of labor. This study was conducted to determine if preterm labor leading to preterm delivery and intra-amniotic infection (IAI) are associated with changes in the amniotic fluid concentrations of MCP-1.Study design. A cross-sectional study was designed to examine the amniotic fluid concentrations of MCP-1 in women in two groups: 1) those presenting with preterm labor with intact membranes; and 2) those with preterm prelabor rupture of membranes ( PROM). Amniotic fluid was obtained by transabdominal amniocentesis from 131 women in preterm labor with intact membranes and 105 women with preterm PROM. IAI was defined by a positive amniotic fluid culture for microorganisms. Group 1 included women with preterm labor and intact membranes ( n = 131), and was subdivided into the following groups: a) delivery at term in the absence of IAI ( n= 42); b) preterm delivery ( 537 weeks) in the absence of IAI ( n = 58); and c) preterm delivery in the presence of IAI ( n = 31). Group 2 consisted of women with PROM ( n= 105), and was subdivided into women with ( n = 51) and without ( n = 54) IAI. Non-parametric statistics were used for data analysis.Results. 1) Immuno-reactive MCP-1 was detected in all amniotic fluid samples; 2) IAI, regardless of the membrane status, was associated with a significantly higher median amniotic fluid concentration of immuno-reactive MCP-1 than those without IAI (p