The Maastricht Study: an extensive phenotyping study on determinants of type 2 diabetes, its complications and its comorbidities
The Maastricht Study: an extensive phenotyping study on determinants of type 2 diabetes, its complications and its comorbidities
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DOI：
10.1007/s10654-014-9889-0
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发表时间：
2014-06-01
影响因子：
13.6
通讯作者：
Stehouwer, Coen D. A.
中科院分区：
文献类型：
--
作者：
Schram, Miranda T.;Sep, Simone J. S.;Stehouwer, Coen D. A.
马斯特里赫特研究是一项广泛的表型研究，重点关注2型糖尿病（T2 DM）的病因、其经典并发症及其新出现的合并症。该研究使用最先进的成像技术和广泛的生物库，以确定10，000人的人群队列中的健康状况，该队列富含T2 DM个体。入组于2010年11月开始，预计持续5-7年。预计马斯特里赫特研究将成为全球一般人群和T2 DM受试者中最广泛的表型研究之一。马斯特里赫特研究将特别关注可能解释T2 DM加速经典并发症（如心血管疾病、视网膜病变、神经病变和肾病）和新出现的合并症（如认知下降、抑郁以及胃肠道、肌肉骨骼和呼吸系统疾病）发生和进展的可能机制。此外，还将研究这些变量与生活质量和医疗资源使用的关联。本文描述了基本原理、总体研究设计、招募策略和基本测量方法，并概述了马斯特里赫特研究中进行的所有测量。
The Maastricht Study is an extensive phenotyping study that focuses on the etiology of type 2 diabetes (T2DM), its classic complications, and its emerging comorbidities. The study uses state-of-the-art imaging techniques and extensive biobanking to determine health status in a population-based cohort of 10,000 individuals that is enriched with T2DM individuals. Enrollment started in November 2010 and is anticipated to last 5-7 years. The Maastricht Study is expected to become one of the most extensive phenotyping studies in both the general population and T2DM participants world-wide. The Maastricht study will specifically focus on possible mechanisms that may explain why T2DM accelerates the development and progression of classic complications, such as cardiovascular disease, retinopathy, neuropathy and nephropathy and of emerging comorbidities, such as cognitive decline, depression, and gastrointestinal, musculoskeletal and respiratory diseases. In addition, it will also examine the association of these variables with quality of life and use of health care resources. This paper describes the rationale, overall study design, recruitment strategy and methods of basic measurements, and gives an overview of all measurements that are performed within The Maastricht Study.