BIOCERAMICS - FROM CONCEPT TO CLINIC
BIOCERAMICS - FROM CONCEPT TO CLINIC
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DOI：
10.1111/j.1151-2916.1991.tb07132.x
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发表时间：
1991-07-01
影响因子：
3.9
通讯作者：
HENCH, LL
中科院分区：
文献类型：
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作者：
HENCH, LL
用于修复和重建肌肉骨骼系统的患病或受损部分的陶瓷（称为生物陶瓷）可以是生物惰性的（氧化铝、氧化锆）、可吸收的（磷酸三钙）、生物活性的（羟基磷灰石、生物活性玻璃和玻璃陶瓷）或用于组织向内生长的多孔的（羟基磷灰石涂层金属、氧化铝）。应用包括髋关节、膝关节、牙齿、肌腱和韧带的置换以及牙周病的修复、颌面重建、颌骨的增强和稳定、脊柱融合和肿瘤手术后的骨填充物。碳涂层具有抗血栓性，用于人工心脏瓣膜。生物活性陶瓷与组织结合的机理已逐渐被人们所了解，这将有助于生物陶瓷与硬组织和软组织界面结合的分子设计。具有高韧性、高弹性模量的骨复合材料正在开发中。癌症的治疗性治疗已经通过经由玻璃珠局部递送放射性同位素来实现。仍然需要制定标准试验方法，用于预测长期（20年）负荷下的机械可靠性。
Ceramics used for the repair and reconstruction of diseased or damaged parts of the musculo-skeletal system, termed bioceramics, may be bio-inert (alumina, zirconia), resorbable (tricalcium phosphate), bioactive (hydroxyapatite, bioactive glasses, and glass-ceramics), or porous for tissue ingrowth (hydroxyapatite-coated metals, alumina). Applications include replacements for hips, knees, teeth, tendons, and ligaments and repair for periodontal disease, maxillofacial reconstruction, augmentation and stabilization of the jaw bone, spinal fusion, and bone fillers after tumor surgery. Carbon coatings are thromboresistant and are used for prosthetic heart valves. The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bio-ceramics for interfacial bonding with hard and soft tissues. Composities are being developed with high toughness and elastic modulus match with bone. Therapeutic treatment of cancer has been achieved by localized delivery of radioactive isotopes via glass beads. Development of standard test methods for prediction of long-term (20-year) mechanical reliability under load is still needed.