Multiple loci on 8q24 associated with prostate cancer susceptibility
Multiple loci on 8q24 associated with prostate cancer susceptibility
复制标题
DOI：
10.1038/ng.452
复制
发表时间：
2009-10-01
期刊：
影响因子：
30.8
通讯作者：
Easton, Douglas F.
中科院分区：
文献类型：
--
作者：
Al Olama, Ali Amin;Kote-Jarai, Zsofia;Easton, Douglas F.
先前的研究已经确定了8q24上的多个位点与前列腺癌风险相关。我们通过5504例前列腺癌病例和5834例对照的基因分型标签SNP，对8q24的SNP关联进行了全面分析。我们证实了先前报道的三个位点的关联，并在另外两个连锁不平衡块中发现了额外的位点(rs1006908：每等位基因OR = 0.87, P = 7.9 x 10(-8)；rs620861: OR = 0.90, P = 4.8 × 10(-8))。5个连锁不平衡区中的8个snp与前列腺癌易感性独立相关。
Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x 10(-8); rs620861: OR = 0.90, P = 4.8 x 10(-8)). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.