Nerve Growth Factor and Transforming Growth Factor-β Serum Levels in Acute Stroke Patients
Nerve Growth Factor and Transforming Growth Factor-β Serum Levels in Acute Stroke Patients
复制标题
DOI：
10.1159/000047710
复制
发表时间：
2001-10
影响因子：
2.9
通讯作者：
L. Stanzani;C. Zoia;G. L. Sala;I. Appollonio;L. Frattola;M. D. Simoni;C. Ferrarese
中科院分区：
文献类型：
--
作者：
L. Stanzani;C. Zoia;G. L. Sala;I. Appollonio;L. Frattola;M. D. Simoni;C. Ferrarese
背景和目的：实验证据表明脑卒中后脑组织中细胞因子和神经营养因子的产生。由于神经营养因子也可以从血细胞中释放，我们测量了40例患者在卒中后不同时间的神经生长因子（NGF）和转化生长因子（TGF）-β血清水平，并将其与20名健康对照者进行了比较。方法：分别于脑卒中后1、4、10、30、90 d抽取静脉血，用ELISA法测定血清中NGF和TGF-β的水平。每个时间点的值与卒中严重程度相关，使用国立卫生研究院卒中量表进行评估，并与卒中后5天进行计算机断层扫描的Cavalieri直接估计器计算的病变体积相关。结果与结论：虽然两组之间没有显着差异被证明，在脑卒中患者中，血清神经营养因子显着相关的临床和神经放射学参数的脑损伤和正相关，在中风的急性期彼此，这表明中风可能会调节外周神经营养因子水平。
Background and Purpose: Experimental evidence indicates cytokine and neurotrophin production in brain tissue after stroke. Since neurotrophins may also be released from blood cells, we measured nerve growth factor (NGF) and transforming growth factor (TGF)-β serum levels in 40 patients at various times after stroke and compared them to those in 20 healthy controls. Methods: Venous blood was obtained 1, 4, 10, 30 and 90 days after stroke and NGF and TGF-β serum levels were measured by commercial ELISA. Values at each time were correlated with stroke severity, assessed using the National Institute of Health Stroke Scale, and with lesion volume, calculated using Cavalieri’s direct estimator on a computerized tomography scan performed 5 days after stroke. Results and Conclusions: Although no significant differences between the two groups were demonstrated, in stroke patients, serum neurotrophins were significantly associated with clinical and neuroradiological parameters of brain injury and positively correlated with each other in the acute phases of stroke, suggesting that stroke may modulate peripheral neurotrophin levels.