A review of neuroimaging studies of anxiety disorders in China.
A review of neuroimaging studies of anxiety disorders in China.
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DOI：
10.2147/ndt.s10997
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发表时间：
2011
影响因子：
3.2
通讯作者：
Shi S
中科院分区：
文献类型：
--
作者：
Chen J;Shi S
焦虑症在国际上非常流行，并且对患者、其家庭和社会构成了巨大的社会和经济负担。在过去的十年中，许多神经影像学研究对中国焦虑症的病因进行了调查。我们讨论了这些研究的结果，并将其与国外焦虑症的神经影像学研究结果进行了比较。使用中国生物医学文献数据库、中国科技期刊数据库、中国期刊全文数据库和PubMed进行了1989年至2009年4月的文献检索。我们选择了所有参与者和研究人员都是中国人的神经影像学研究。25项研究符合我们的纳入标准。9项研究检查了广泛性焦虑症（GAD）和/或惊恐障碍（PD），8项检查了强迫症（OCD），8项检查了创伤后应激障碍（PTSD）。我们的文献回顾揭示了几个一般性的发现。首先，与健康对照组相比，GAD和PD患者的额叶和颞叶局部脑血流量（rCBF）减少。第二，当观看具有负和正效价的图像时，分别在GAD和PD患者的几个脑区中发现相对增加或减少的激活。第三，正电子发射断层扫描（PET）和磁共振波谱（MRS）成像的研究显示，与健康对照组相比，强迫症患者在某些脑区表现出高灌注和低灌注。创伤后应激障碍的神经影像学研究表明，与对照组相比，创伤后应激障碍患者的海马体积和海马中的N-乙酰天冬氨酸（NAA）水平以及NAA/肌酸比值降低。国内外的神经影像学研究提供了与焦虑症相关的特定神经生物学改变的证据。然而，在对具有相同诊断的患者进行的不同研究中，结果并不完全一致。今后应开展使用大样本和稳健设计的国际合作研究。
Anxiety disorders are highly prevalent internationally, and constitute a substantial social and economic burden for patients, their families, and society. A number of neuroimaging studies have investigated the etiology of anxiety disorders in China in the last decade. We discuss the findings of these studies, and compare them with the results of neuroimaging studies of anxiety disorders outside China. A literature search was conducted using the Chinese BioMedical Literature Database, the Chinese Scientific and Technical Periodicals Database, the Chinese Journal Full-text Database, and PubMed, from 1989 to April 2009. We selected neuroimaging studies in which all participants and researchers were Chinese. Twenty-five studies fit our inclusion criteria. Nine studies examined general anxiety disorder (GAD) and/or panic disorder (PD), eight examined obsessive-compulsive disorder (OCD), and eight examined posttraumatic stress disorder (PTSD). Our literature review revealed several general findings. First, reduced regional cerebral blood flow (rCBF) was found in the frontal lobe and temporal lobe in patients with GAD and PD compared with healthy controls. Second, when viewing images with negative and positive valence, relatively increased or decreased activation was found in several brain areas in patients with GAD and PD, respectively. Third, studies with positron emission tomography (PET) and magnetic resonance spectroscopy (MRS) imaging revealed that OCD patients exhibited hyperperfusion and hypoperfusion in some brain regions compared with healthy controls. Neuroimaging studies of PTSD indicate that the hippocampal volume and the N-acetylaspartic acid (NAA) level and the NAA/creatine ratio in the hippocampus are decreased in patients relative to controls. Neuroimaging studies within and outside China have provided evidence of specific neurobiological changes associated with anxiety disorders. However, results have not been entirely consistent across different studies of patients with the same diagnoses. International collaborative research using large samples and robust designs should be conducted in future.