Between-slice intervals in quantification of adipose tissue and muscle in children
Between-slice intervals in quantification of adipose tissue and muscle in children
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DOI：
10.3109/17477166.2010.486833
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发表时间：
2011-04-01
影响因子：
--
通讯作者：
Heymsfield, Steven B.
中科院分区：
文献类型：
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作者：
Shen, Wei;Chen, Jun;Heymsfield, Steven B.
磁共振成像（MRI）越来越多地用于儿童体内量化脂肪组织（AT）和骨骼肌（SM）。目前尚不清楚成人使用的每5 cm全身MRI方案是否适用于儿童。对73名5-17岁的健康儿童进行了1cm厚的连续全身MRI扫描。将图像分割为皮下（SAT）、内脏（VAT）、肌间AT（IMAT）和SM。通过连续协议测量的体积与通过不同切片间间隔的协议估计的体积之间的百分比差异（即，间隔= 2、3、4和5 cm）随着间隔大小、储库大小、体重和体重指数百分位数的增加而增大。对于组比较，如果使用每5 cm方案获得与每1 cm方案相同的把握度，则研究将需要不到5.4%的更多受试者。对于个体受试者比较，间期方案可用于可靠区分SM或SAT体积相差0.14至0.64 L的受试者（即，SM或SAT体积的1%至5%）或更多，或在VAT或IMAT体积中增加0.06至0.21 L（即，增值税或IMAT量的10%至30%）或更多。对于儿童的组比较以及单个儿童之间的SM和SAT比较，每5 cm图像采集协议可以被认为与连续协议一样准确。然而，更小的切片间隔协议将更准确地比较增值税或IMAT个别儿童。
Magnetic Resonance Imaging (MRI) is increasingly being used in children to quantify adipose tissue (AT) and skeletal muscle (SM) in vivo. It is unclear whether the every 5 cm whole body MRI protocol used in adults is appropriate when applied in children. Whole body MRI continuous 1 cm thick slices were acquired in 73, aged 5-17-year-old healthy children. Images were segmented into subcutaneous (SAT), visceral (VAT), intermuscular AT (IMAT), and SM. The percentage difference between volumes measured by the continuous protocol and volumes estimated with protocols of different between-slice intervals (i.e., interval = 2, 3, 4 and 5 cm) was larger with an increase in interval size, depot size, weight and body mass index percentile. For group comparisons, studies will require less than 5.4% more subjects if an every 5 cm protocol is used for equivalent power as the every 1 cm protocol. For individual subject comparisons, interval protocols can be used to reliably distinguish between subjects who differ in SM or SAT volume by 0.14 to 0.64 L (i.e., 1 to 5% of SM or SAT volume) or more, or in VAT or IMAT volume by 0.06 to 0.21 L (i.e., 10 to 30% of VAT or IMAT volume) or more. The every 5 cm image acquisition protocol can be considered as accurate as the contiguous protocol for group comparisons in children, as well as for comparison of SM and SAT among individual children. However, a smaller slice interval protocol would be more accurate for comparison of VAT or IMAT among individual children.