What is an epitheliome, anyway?
What is an epitheliome, anyway?
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到底什么是上皮组？
DOI：
10.1016/j.ibmb.2015.10.013
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发表时间：
2015
影响因子：
3.8
通讯作者：
Dow JA
中科院分区：
文献类型：
--
作者：
Dow JA
昆虫是非常成功的一类生命，其物种（> 10 M）与所有其他类生物的总和一样多。他们是如何成功地利用如此多样化的生态位的？任何昆虫生物学家都可以为任何行为、器官或生理过程的重要性提出令人信服的理由;毕竟，我们今天在昆虫身上看到的一切都是500 My进化完善的产物。然而，毫无疑问，陆地和水中的昆虫都必须维持一个内部环境，该环境受到严格的稳态调节，并且与外部世界不同。上皮细胞或细胞片的任务是保持昆虫与外界隔离，并将昆虫内部的不同领域分开。因此，上皮组是一个概念分组的所有过程，表达的基因或蛋白质，构成一个功能性上皮，并区分他们从其他epitheli.In这卷，我们采取综合的方法隐含在我们的定义的上皮组，问一些经典的昆虫上皮（例如外皮，消化道，肾小管）的成功作出贡献的昆虫纲。当然，这其中隐含着一个应用上的好处，即药物破坏昆虫上皮细胞可以为昆虫控制提供新的、更具选择性的工具。当然，这种方法已经有了先例：苏云金芽孢杆菌证明了破坏肠道上皮完整性的灾难性影响。
Insects are extraordinarily successful class of life, with as many species (> 10M) as all other classes of living organism combined. How are they so successful in exploiting such a diverse range of ecological niches? Any insect biologist could make a convincing case for the importance of any behaviour, organ or physiological process; after all, everything we see in insects today is the product of 500 My of evolutionary refinement. Indubitably though, insects both on land and in water must maintain an internal milieu that is closely regulated homeostatically, and distinct from the outside world. Epithelia, or sheets of cells, are tasked with keeping both the insect separate from the outside world, and with separating different domains within the insect. An epitheliome is thus a conceptual grouping of all of the processes, expressed genes or proteins that make up a functional epithelium, and distinguish them from other epithelia.In this volume, we take the integrative approach implicit in our definition of the epitheliome to ask how some of the classical insect epithelia (for example integument, alimentary canal, renal tubules) contribute to the success of Class Insecta. Implicit in this, of course is an applied benefit–that pharmacological disruption of insect epithelia could provide new, more selective tools for insect control. There is already a precedent for such an approach, of course: Bacillus thuringiensis demonstrates the catastrophic impact of disruption of gut epithelial integrity.