Psychopathological Symptoms Assessed by a System-Specific Approach Are Related to Global Functioning in Schizophrenic Disorders
Psychopathological Symptoms Assessed by a System-Specific Approach Are Related to Global Functioning in Schizophrenic Disorders
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DOI：
10.1159/000444505
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发表时间：
2016-01-01
期刊：
影响因子：
3.6
通讯作者：
Jaeger, Markus
中科院分区：
文献类型：
--
作者：
Lang, Fabian U.;Mueller-Stierlin, Annabel S.;Jaeger, Markus
背景：通过主要使用积极-消极的方法，一些研究已经确定了影响日常功能的因素。我们应用了一种不同的、特定于系统的方法来扩展对这个问题的认识。样本和方法：我们招募了100名诊断为精神分裂症或分裂情感性障碍的DSM-IV住院患者。用Bern精神病理量表（BPS）评估精神病理特征，用整体功能评估量表（GAF）评估功能特征。以GAF评分为因变量，BPS总分为自变量，进行线性回归分析。该模型控制了混杂变量。Spearman秩相关分析用于确定相关BPS子域与整体功能之间的关联。结果：较高的BPS域语言（p = 0.038）和运动行为（p = 0.049）的绝对全局值与较低的GAF分数显著相关。在调整了潜在的混杂变量后，这些发现保持稳定。语言域和GAF得分的定性症状（r = -0.273, p = 0.006）和间接症状（r = -0.269, p = 0.007）之间存在统计学上显著的负相关。此外，运动行为领域的定量症状（r = -0.211, p = 0.035）和定性症状（r = -0.214, p = 0.033）与较差的功能相关。结论：系统特异性方法可以描述功能不良患者的亚组。识别这些亚群有助于及时利用有针对性的治疗意见。未来研究的另一个目标是阐明潜在的神经生物学缺陷。(c) 2016 S. Karger AG，巴塞尔
Background: By mostly using a positive-negative approach, several studies have identified factors that influence day-today functioning. We applied a different, system-specific approach to expand the knowledge of this issue. Sampling and Methods: We recruited a sample of 100 inpatients with a DSM-IV diagnosis of schizophrenia or schizoaffective disorder. Psychopathological characteristics were assessed with the Bern Psychopathology Scale (BPS) and functional characteristics with the Global Assessment of Functioning (GAF) scale. Linear regression analyses were performed with the GAF score as the dependent variable and the global values of the BPS subscores as independent variables. The model was controlled for confounding variables. Spearman rank correlation analyses were used to identify associations between the relevant BPS subdomains and global functioning. Results: Higher absolute global values of the BPS domains language (p = 0.038) and motor behavior (p = 0.049) were significantly associated with lower GAF scores. These findings remained stable after adjusting for potential confounding variables. A statistically significant negative correlation was found between both qualitative symptoms (r = -0.273, p = 0.006) and indirect signs (r = -0.269, p = 0.007) of the language domain and GAF scores. Also, quantitative (r = -0.211, p = 0.035) and qualitative symptoms (r = -0.214, p = 0.033) in the motor behavior domain were associated with poorer functioning. Conclusions: A system-specific approach can describe subgroups of patients with poor functioning. Identifying such subgroups could help to utilize targeted treatment opinions in a timely manner. Another goal of future research is to clarify the underlying neurobiological deficits. (c) 2016 S. Karger AG, Basel