Antibacterial and antiviral naphthazarins from Maharanga bicolor
Antibacterial and antiviral naphthazarins from Maharanga bicolor
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DOI：
10.1691/ph.2007.8.6785
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发表时间：
2007-08-01
期刊：
影响因子：
1.6
通讯作者：
Lindequist, U.
中科院分区：
文献类型：
--
作者：
Rajbhandari, M.;Schoepke, Th.;Lindequist, U.
马哈兰加双色，紫草科，在尼泊尔民族医药中被用于治疗几种疾病。在筛选调查过程中，发现二色马哈拉加根部二氯甲烷提取物对革兰氏阳性菌有生长抑制作用。生物测定定向分离得到5个活性氮杂环丙烷类化合物，分别为脱氧甘草素(1)、甘草素(2)、乙酰甘草素(3)、甘草素β-羟基异戊酸酯(4)和甘草素β-乙酰氧基异戊酸酯(5)。化合物2-5对多重耐药的人致病葡萄球菌和肠球菌具有抗菌活性，化合物1、4和5对单纯疱疹病毒1型具有抗病毒活性。
Maharanga bicolor, Boraginaceae, is used in the Nepalese ethnomedicine for the treatment of several diseases. In the course of screening investigations the dichloromethane extract of the roots of Maharanga bicolor was found to inhibit the growth of gram positive bacteria. Bio-assay directed fractionation led to the isolation of five active naphthazarins, deoxyalkannin (1), alkannin (2), acetylalkannin (3), alkannin beta-hydroxyisovalerate (4) and alkannin beta-acetoxyisovale rate (5). Compounds 2-5 showed antibacterial activity against multi resistant human pathogenic Staphylococcus and Enterococcus species and 1, 4 and 5 showed antiviral activity against herpes simplex virus type-1.