Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population
Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population
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DOI：
10.2337/db07-0979
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发表时间：
2008-03-01
期刊：
影响因子：
7.7
通讯作者：
Maeda, Shiro
中科院分区：
文献类型：
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作者：
Mori, Shintaro;Tanaka, Yasushi;Maeda, Shiro
客观地，几种基因被证明与白人种群中基因组广泛关联研究的2型糖尿病风险增加有关。为了进一步研究这些多态性参与对2型糖尿病的敏感性，我们检查了11个候选基因座中14个单核苷酸多态性（SNP）与日本人群中的2型糖尿病的关联。研究和方法分析了14个SNPS，并分析了14个SNPS （RS4402960在IGF2BP2中，RS10811661中的CDKN2A/B，RS1111875和RS7923837在HHEX中，RS13266634，SLC30A8中的RS13266634 992在CDKAL1中，RS1801282在PPARG PRO12ARA中，rs5219 in Kcnj11 Glu23lys，rs7480010，loc387761 ，CH11中的RS9300039）在1,630名日本受试者中患有2型糖尿病和1,064名对照受试者，使用入侵者测定或taqman Assay。检查的11个位点，检查的6个位点与我们的种群有显着相关。逻辑回归分析类似于先前报道的结果（rs4402960，p = 0.00009； rs10811661，p = 0.0024; rs5219; rs5219，p = 0.0034; rs1111875; rs1111875，p = 0.0064; rs132666634，p = 0.0073; RS7756992，p = 0.0363）。在该人群中，其余五个基因座与2型糖尿病没有显着相关。此外，我们确定了FTO基因中的SNP与BMI在对照主题中的显着关联。结论 - 我们已经确定了通过基因组全体研究在白人种群中鉴定出的11个基因座中的6个，这些基因群被认为是强大的候选者。对于不同种族的2型糖尿病易感性。
OBJECTIVE-Recently, several genes have been shown to be associated with an increased risk of type 2 diabetes by genome wide association studies in white populations. To further investigate the involvement of these polymorphisms in conferring susceptibility to type 2 diabetes, we examined the association of 14 single nucleotide polymorphisms (SNPs) within 11 candidate loci with type 2 diabetes in a Japanese population.RESEARCH DESIGN AND METHODS-We analyzed 14 SNPs (rs4402960 in IGF2BP2, rs10811661 in CDKN2A/B, rs1111875 and rs7923837 in HHEX, rs13266634 in SLC30A8, rs1113132 and rs11037909 in EXT2, rs9939609 and rs8050136 in FTO, rs7756992 in CDKAL1, rs1801282 in PPARG Pro12Ara, rs5219 in KCNJ11 Glu23Lys, rs7480010 in LOC387761, and rs9300039 in Ch11) in 1,630 Japanese subjects with type 2 diabetes and in 1,064 control subjects by using an invader assay or a TaqMan assay.RESULTS-Among the 11 loci examined, 6 were significantly associated with type 2 diabetes in our population by a logistic regression analysis, similar to previously reported results (rs4402960, P = 0.00009; rs10811661, P = 0.0024; rs5219, P = 0.0034; rs1111875, P = 0.0064; rs13266634, P = 0.0073; rs7756992, P = 0.0363). In this population, the remaining five loci were not significantly associated with type 2 diabetes. In addition, we identified significant association of the SNPs in FTO gene with BMI in the control subjects.CONCLUSIONS-We have identified 6 of the 11 loci that were identified by genome-wide association studies in white populations, and these loci are considered strong candidates for type 2 diabetes susceptibility across different ethnicities.