The pak4 protein kinase in breast cancer.
The pak4 protein kinase in breast cancer.
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DOI：
10.5402/2012/694201
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Minden A
中科院分区：
文献类型：
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作者：
Minden A
Paks4、Paks5和paks6是p21活化激酶（Paks） B组家族的成员。Paks在控制细胞形态、细胞生长、增殖和信号传导方面发挥着多种不同的作用。Pak4在胚胎发育中起重要作用（Qu et al., 2003），但在成人中，高水平的Pak4通常与癌症有关。Pak4与几种类型的癌症有关（Wells和Jones, 2010； Eswaran等人，2009；Liu等人，2008；and Liu等人，2010），并且与乳腺癌密切相关（Liu等人，2008；Liu等人，2010；Yu等人，2009；Rafn等人，2012；So等人，2012）。乳腺肿瘤和乳腺癌细胞系通常具有高水平的Pak4 (Liu et al., 2008)，并且Pak4在乳腺上皮细胞中过表达导致小鼠肿瘤发生（Liu et al., 2010）。本文就Pak4在乳腺癌中的作用的研究进展进行综述。
Paks4, along with Paks5, and 6 are members of the group B family of p21-activated kinases (Paks). The Paks play multiple different roles in controlling cell morphology, cell growth, proliferation, and signaling. Pak4 has essential roles in embryonic development (Qu et al., 2003), but in adults high levels of Pak4 are frequently associated with cancer. Pak4 has been implicated in several types of cancer (Wells and Jones, 2010; Eswaran et al., 2009; Liu et al., 2008; and Liu et al., 2010) and it is strongly linked to breast cancer (Liu et al., 2008; Liu et al. 2010; Yu et al., 2009; Rafn et al., 2012; and So et al., 2012). Breast tumors and breast cancer cell lines frequently have high levels of Pak4 (Liu et al., 2008), and overexpression of Pak4 in mammary epithelial cells leads to tumorigenesis in mice (Liu et al., 2010). This paper summarizes the current work on the role of Pak4 in breast cancer.