FURTHER-STUDIES ON HUMAN ENTERIC CORONAVIRUSES
FURTHER-STUDIES ON HUMAN ENTERIC CORONAVIRUSES
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DOI：
10.1007/bf01314383
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发表时间：
1977-01-01
影响因子：
2.7
通讯作者：
EGGLESTONE, SI
中科院分区：
文献类型：
--
作者：
CAUL, EO;EGGLESTONE, SI
进行了比较，通过阴性染色与猪和小牛的肠肠病毒与肠道冠状病毒进行了比较。接种人肠冠状病毒后，以各种时间间隔对人肠道器官培养液的检查显示出液体中颗粒数量的增加。这些外植体的柱状上皮细胞的薄部分显示出许多与已知的人和动物冠状病毒复制一致的特征。在薄部分中发现的病毒颗粒的平均直径为68 nm。在薄片中发现了一个结构，该结构先前没有描述。该结构可能代表病毒核蛋白酶。
Comparisons were made between human enteric conronaviruses and the enteric coronaviruses of pigs and calves by negative staining. Examination of human intestinal organ culture fluids at various time intervals after inoculation with the human enteric coronavirus showed increasing numbers of particles in the fluids. Thin sections of the columnar epithelial cells of these explants showed a number of features consistent with the replication of known human and animal coronaviruses. Virus particles found in thin sections had a mean diameter of 68 nm. A structure was found in thin sections which was not described previously. This structure may represent the viral nucleocapsid.