EFFECT OF LYSO-PHOSPHATIDYLSERINE ON RAT HYPOTHALAMIC CAMP, INVIVO
EFFECT OF LYSO-PHOSPHATIDYLSERINE ON RAT HYPOTHALAMIC CAMP, INVIVO
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DOI：
10.1016/0024-3205(81)90502-6
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发表时间：
1981-01-01
期刊：
影响因子：
6.1
通讯作者：
TOFFANO, G
中科院分区：
文献类型：
--
作者：
CALDERINI, G;TEOLATO, S;TOFFANO, G
溶血磷脂酰丝氨酸与其前体磷脂酰丝氨酸一样，可增加大鼠下丘脑中cAMP的浓度。这种作用呈剂量依赖性，在注射后10-20分钟达到最大值。抗肾上腺素能药物利血平、α-甲基-对酪氨酸(α-MPT)、氟哌啶醇和氯丙嗪可阻止溶血磷脂酰丝氨酸诱导的下丘脑cAMP蓄积，但酚妥拉明和心得安无此作用。5-羟色胺能、组胺能、胆碱能和GABA能药物不能改变溶血磷脂酰丝氨酸效应。多巴胺能系统可能参与了溶血磷脂酰丝氨酸的药理作用。
Lysophosphatidylserine, like its precursor phosphatidylserine, increases the concentration of cAMP in the rat hypothalamus. The effect is dose-dependent and reaches its maximum 10-20 min from the injection. Antiadrenergic drugs, i.e., reserpine, .alpha.-methyl-p-tyrosine (.alpha.-MpT), haloperidol and chlorpromazine, but not phentolamine or propranolol, prevent the accumulation of hypothalamic cAMP induced by lysophosphatidylserine. Serotoninergic, histaminergic, cholinergic and GABAergic drugs do not modify the lysophosphatidylserine effect. The dopaminergic system may be involved in the mediation of the pharmacological effect of lysophosphatidylserine.