The role of Toll-like receptors in the host response to viruses
The role of Toll-like receptors in the host response to viruses
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DOI：
10.1016/j.molimm.2004.11.007
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发表时间：
2005-05-01
影响因子：
3.6
通讯作者：
Haga, IR
中科院分区：
文献类型：
--
作者：
Bowie, AG;Haga, IR
Toll样受体（TLR）的发现彻底改变了我们对先天免疫的理解。在过去的几年里，关于这个问题已经写了许多评论。在这里，我们审查的证据表明，TLR参与感应和启动抗病毒反应。现在有三个强有力的证据支持TLR的这种作用。首先，TLR“识别”病毒衍生的分子，并且是各种病毒诱导的细胞效应所需的。其次，TLR触发抗病毒信号传导途径，导致干扰素应答的诱导。第三。已经鉴定了针对TLR的病毒免疫策略。(c)2004爱思唯尔有限公司保留所有权利。
The discovery of Toll-like receptors (TLR) has revolutionised our understanding of innate immunity. Numerous reviews have been written on the Subject in the past few years. Here, we review the evidence that TLRs are involved in sensing and initiating anti-viral responses. There are now three strong lines of evidence that support such a role for TLRs. Firstly, TLRs 'recognise' virally derived molecules and are required for various virus-induced cellular effects. Secondly, TLRs trigger anti-viral signalling pathways leading to the induction of the interferon response. Thirdly. viral immuine strategies employed against TLRs have been identitied. (c) 2004 Elsevier Ltd. All rights reserved.