Male microchimerism and survival among women
Male microchimerism and survival among women
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DOI：
10.1093/ije/dyt230
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发表时间：
2014-02-01
影响因子：
7.7
通讯作者：
Tjonneland, Anne
中科院分区：
文献类型：
--
作者：
Kamper-Jorgensen, Mads;Hjalgrim, Henrik;Tjonneland, Anne
背景：妊娠期间，妇女和胎儿之间交换少量的细胞，这种细胞持续存在的现象称为微嵌合体。众所周知，微嵌合体对女性日后的健康有很大影响。本研究根据男性微嵌合体状态来检验女性的存活率。方法1993年至1997年，对丹麦饮食、癌症和健康队列中272名年龄在50-之间的女性进行了男性微嵌合体存在的检测，测量外周血Y染色体。丹麦国家登记的妇女因特定死因死亡接受跟踪，直至2009年底。结果男性微嵌合体阳性190例(70%)。在随访期间，21名女性死亡，其中11名(52%)登记时男性微嵌合体阳性，10名阴性。在21例死亡病例中，13例(62%)死于癌症，5例(24%)死于心血管疾病。男性微嵌合体的存在与全因死亡率降低的风险比为0.42(95%可信区间0.17-1.03)相关。与阴性女性相比，男性微嵌合体阳性者死于癌症和心血管疾病的风险比分别为0.24(95%CI 0.08~0.79)和1.66(95%CI 0.18~15.48)。结论虽然其生物学机制尚不明确，但女性外周血中男性微嵌合体的存在与女性存活率的显著提高有关。结果还表明，不同的死因与男性微嵌合体的关联可能有所不同。
Background During pregnancy, woman and fetus exchange small quantities of cells, and their persistence at later times is termed microchimerism. Microchimerism is known to substantially impact on women's later health. This study examined the survival of women according to male microchimerism status.Methods Male microchimerism presence, measured as Y chromosome in peripheral blood samples, was determined in 272 women from the large Danish Diet, Cancer and Health cohort when aged 50-64 years during 1993-97. Women were followed up for cause-specific death in national Danish registers until the end of 2009. Survival was analysed using Cox regression.Results A total of 190 women (70%) were male microchimerism positive. During follow-up 21 women died, of whom 11 (52%) were male microchimerism positive at enrolment and 10 were negative. Of the 21 deaths, 13 (62%) were due to cancer and 5 (24%) were due to cardiovascular disease. Male microchimerism presence was associated with a reduced hazard ratio of all-cause mortality of 0.42 (95% CI 0.17-1.03). The hazard ratio of death from cancer and cardiovascular disease was 0.24 (95% CI 0.08-0.79) and 1.66 (95% CI 0.18-15.48), respectively, among male microchimerism positive compared with negative women.Conclusions Although the biological mechanisms are not precisely known, male microchimerism presence in peripheral blood of women is associated with substantially improved survival in women. The results also indicate that the association with male microchimerism may vary between different causes of death.