Relationship between proliferative activity and estrogen receptors in breast cancer
Relationship between proliferative activity and estrogen receptors in breast cancer
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乳腺癌增殖活性与雌激素受体的关系
DOI：
10.1002/1097-0142(197908)44:2
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发表时间：
1979
期刊：
影响因子：
6.2
通讯作者：
G. Fronzo
中科院分区：
文献类型：
--
作者：
R. Silvestrini;M. Daidone;G. Fronzo
乳腺癌的增殖活性进行了分析有关的激素特性的主机和199例患者的肿瘤。对绝经前和绝经后患者雌激素受体阳性（ER+）和阴性（ER-）癌症的标记指数频率分布的分析使我们能够确定三个不同的动力学组。第一组具有非常低的增殖活性，包括来自绝经后患者的ER+癌症;第二组具有中等增殖活性，包括来自绝经前患者的ER+癌症和来自绝经后患者的ER-癌症;第三组具有非常高的增殖活性，包括来自绝经前患者的ER-癌症。通常，ER+癌症中雌激素受体的量与增殖活性呈负相关。低增殖活性肿瘤患者绝经前雌激素受体水平较绝经后患者低。癌症44：665 - 670，1979年。
The proliferative activity of breast cancer has been analyzed in relation to the hormonal characteristics of the host and of the tumor for 199 patients. The analyses of labeling index frequency distributions of estrogen receptor positive (ER+) and negative (ER‐) cancers from premenopausal and postmenopausal patients have allowed us to identify three different kinetic groups. A first group, with a very low proliferative acitivty, includes ER+ cancers from postmenopausal patients; a second group, with an intermediate proliferative activity, includes ER+ cancers from premenopausal and ER‐ cancers from postmenopausal patients; and a third group, with a very high proliferative activity, includes ER‐ cancers from premenopausal patients. Generally, the amount of estrogen receptors in ER+ cancers is inversely correlated with the proliferative activity. Lower levels of ER in premenopausal in comparison to postmenopausal patients were found in low proliferative activity tumors. Cancer 44:665‐670, 1979.