Caveolin-1, a novel player in cognitive decline.
Caveolin-1, a novel player in cognitive decline.
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Caveolin-1，认知衰退的新参与者。
DOI：
10.1016/j.neubiorev.2021.06.044
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Wang Qiang
中科院分区：
文献类型：
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作者：
Tang Wenxin;Li Yansong;Li Yan;Wang Qiang
认知能力下降（CD）与血管性痴呆、阿尔茨海默病、帕金森病、亨廷顿病、肌萎缩侧索硬化症和糖尿病等疾病有关，是一个日益受到关注的健康问题，对患者的生活质量有很大影响。尽管进行了广泛的努力，但乳糜泻的发病机制仍远未明确，更不用说有效的治疗和预防策略了。小窝蛋白-1 （Cav-1）是一种跨膜蛋白，是小窝结构蛋白和支架蛋白的主要组成部分。最近，大量证据表明Cav-1与CD之间存在很强的相关性，然而，Cav-1在CD中的具体作用尚未得到明确的研究，它们之间的联系也尚未确定。本文旨在全面概述Cav-1如何调节cd相关疾病的发病机制。综上所述，Cav-1可以促进神经元的结构和功能可塑性，促进神经发生，缓解线粒体功能障碍，抑制炎症，抑制氧化应激，提示Cav-1可能是治疗CD的有效靶点。
Cognitive decline (CD), which related to vascular dementia, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis and diabetes mellitus, is a growing health concern that has a great impact on the patients' quality of life. Although extensive efforts, the mechanisms of CD are still far from being clarified, not to mention the effective treatment and prevention strategies. Caveolin-1 (Cav-1), a trans-membrane protein, is a major component of the caveolae structure and scaffolding proteins. Recently, ample evidence depicts a strong correlation between Cav-1 and CD, however, the specific role of Cav-1 in CD has not been clearly examined and how they might be connected have yet to be identified. This review seeks to provide a comprehensive overview about how Cav-1 modulates pathogeneses of CD-associated diseases. In summary, Cav-1 can promote structural and functional plasticity of neurons, improve neurogenesis, relieve mitochondrial dysfunction, inhibit inflammation and suppress oxidative stress, which have shed light on the idea that Cav-1 may be an efficacious therapeutic target to treat CD.