Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis.
Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis.
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DOI：
10.3390/ijms160920560
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发表时间：
2015-08-31
影响因子：
5.6
通讯作者：
Mobasheri A
中科院分区：
文献类型：
--
作者：
Musumeci G;Castrogiovanni P;Trovato FM;Weinberg AM;Al-Wasiyah MK;Alqahtani MH;Mobasheri A
在骨关节炎（OA）软骨中检测到细胞凋亡的形态学和分子特征，这表明软骨细胞死亡/存活在OA发病过程中起关键作用。鉴定软骨细胞凋亡的生物标志物可能有助于开发新的治疗方法，从而消除骨性关节炎的病因或至少减缓骨性关节炎的退行性过程。本文旨在探讨骨性关节炎中诱导软骨细胞凋亡的分子标志物和信号。在PubMed、Scopus、Web of Science和谷歌Scholar中检索相关文献，检索关键词为软骨细胞死亡、细胞凋亡、骨关节炎、自噬和生物标志物。几个被认为是软骨细胞凋亡标志物的分子将在这篇简短的综述中讨论。与软骨细胞凋亡相关的分子标记和信号通路可能成为OA的治疗靶点，旨在中和诱导凋亡的分子的方法至少可以延缓OA软骨退变的进展。
Cell death with morphological and molecular features of apoptosis has been detected in osteoarthritic (OA) cartilage, which suggests a key role for chondrocyte death/survival in the pathogenesis of OA. Identification of biomarkers of chondrocyte apoptosis may facilitate the development of novel therapies that may eliminate the cause or, at least, slow down the degenerative processes in OA. The aim of this review was to explore the molecular markers and signals that induce chondrocyte apoptosis in OA. A literature search was conducted in PubMed, Scopus, Web of Science and Google Scholar using the keywords chondrocyte death, apoptosis, osteoarthritis, autophagy and biomarker. Several molecules considered to be markers of chondrocyte apoptosis will be discussed in this brief review. Molecular markers and signalling pathways associated with chondroycte apoptosis may turn out to be therapeutic targets in OA and approaches aimed at neutralizing apoptosis-inducing molecules may at least delay the progression of cartilage degeneration in OA.