Transformation of olfactory representations in the Drosophila antennal lobe
Transformation of olfactory representations in the Drosophila antennal lobe
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DOI：
10.1126/science.1090782
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发表时间：
2004-01-16
期刊：
影响因子：
56.9
通讯作者：
Laurent, G
中科院分区：
文献类型：
--
作者：
Wilson, RI;Turner, GC;Laurent, G
分子遗传学揭示了初级嗅觉感觉神经元向次级嗅觉感觉神经元投射的精确模式。一个主要的挑战是理解这种映射如何转化为这些二级神经元的气味反应。我们在果蝇体内使用全细胞记录研究了这个问题。我们观察到，单分子气味通常在天线叶神经元的大集合中引起反应。对同一肾小球传入神经和突触后神经元气味诱发活动的比较显示，二级神经元比初级传入神经表现出更广泛的调谐和更复杂的反应。这表明气味表征的主要转变，暗示了触角叶内的横向相互作用。
Molecular genetics has revealed a precise stereotypy in the projection of primary olfactory sensory neurons onto secondary neurons. A major challenge is to understand how this mapping translates into odor responses in these second-order neurons. We investigated this question in Drosophila using whole-cell recordings in vivo. We observe that monomolecular odors generally elicit responses in large ensembles of antennal lobe neurons. Comparison of odor-evoked activity from afferents and postsynaptic neurons in the same glomerulus revealed that second-order neurons display broader tuning and more complex responses than their primary afferents. This indicates a major transformation of odor representations, implicating lateral interactions within the antennal lobe.