Updated review on immune factors in pathogenesis of Crohn’s disease
Updated review on immune factors in pathogenesis of Crohn’s disease
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DOI：
10.3748/wjg.v24.i1.15
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
施瑞华
中科院分区：
文献类型：
--
作者：
李娜;施瑞华
China is not as high as that in European and American .countries, there has been a clear increasing trend in .recent years. Little is known about its pathogenesis, .cause of deferment, and the range of complications .associated with the disease. Local and international .scholars have presented many hypotheses about .CD pathogenesis based on experimental and clinical .studies, including genetic susceptibility, immune .function defects, intestinal microflora disorders, delayed .hypersensitivity, and food antigen stimulation. However, .the specific mechanism leading to this immune .imbalance, which causes persistent intestinal mucosal .damage, and the source of the inflammatory cascade .reaction are still unclear. So far, the results of research .studies differ locally and internationally. This paper .presents the most current research on immune factors .in the pathogenesis of CD.
