"Transdifferentiation" of C6 glial cells in culture.
"Transdifferentiation" of C6 glial cells in culture.
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DOI：
10.1126/science.6102413
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发表时间：
1980-04
期刊：
影响因子：
56.9
通讯作者：
K. Parker;M. Norenberg;A. Vernadakis
中科院分区：
文献类型：
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作者：
K. Parker;M. Norenberg;A. Vernadakis
在传代早期(21~26代)和传代后期(82~88代)，研究了少突胶质细胞的酶标记物环核苷酸磷酸水解酶和星形胶质细胞的酶标记物谷氨酰胺合成酶的活性。在早期传代中，环核苷酸磷酸水解酶活性明显较高，而谷氨酰胺合成酶活性较低，而在传代后期则相反。这些发现表明，C6神经胶质细胞在培养中传代后发生了“转分化”。
The activities of cyclic nucleotide phosphohydrolase, an enzyme marker for oligodendrocytes, and glutamine synthetase, an enzyme marker for astrocytes, were studied at early (21 to 26) and late (82 to 88) cell passages. The activity of cyclic nucleotide phosphohydrolase was markedly high and that of glutamine synthetase was low in the early passages, but this relation was reversed in the late passages. These findings suggest a "transdifferentiation" of C6 glial cells with passage in culture.