Well-being, health-related quality of life and cardiovascular disease risk profile in women with subclinical thyroid disease - a community-based study
Well-being, health-related quality of life and cardiovascular disease risk profile in women with subclinical thyroid disease - a community-based study
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DOI：
10.1111/j.1365-2265.2007.02771.x
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发表时间：
2007-04-01
影响因子：
3.2
通讯作者：
Davis, Susan R.
中科院分区：
文献类型：
--
作者：
Bell, Robin J.;Rivera-Woll, Livia;Davis, Susan R.
目的本研究的目的是评估亚临床甲状腺疾病是否与健康相关的生活质量受损和更不利的心血管疾病的风险profiles.Design一个基于社区的横断面研究。从2002年4月至2003年8月，通过选民名册从社区随机招募18-75岁的人。主要结果测量这些是SF-36的得分，心理总体幸福感指数（PGWI）、甲状腺激素水平、血脂及高敏C反应蛋白（hsCRP）。亚临床甲减（SCH）和亚临床甲亢（SCHyper）分别定义为血清TSH > 4.0 mIU/l和< 0.5 mIU/l，游离甲状腺素（游离T4）水平正常。10.7%的妇女TSH值异常。按年龄组划分的低TSH水平的患病率范围为1.2%至6.4%，而TSH水平升高的患病率范围为2.8%至9.2%，并随年龄增加而增加（P = 0.002）。SCH或SCHyper女性与年龄匹配的对照组之间的总PGWI评分或SF-36的精神和身体成分评分无显著差异。SCH女性患者的血脂或hsCRP与对照组无差异。使用线性回归，SCH与甲状腺功能正常对总胆固醇或甘油三酯的变化没有独立贡献，有或没有年龄+/-年龄（2）+/- BMI的调整。结论我们的数据表明，社区妇女的亚临床甲状腺疾病与较低的幸福感或健康受损无关。相关的生活质量和SCH与CVD风险的血清标志物增加无关。
Objectives The aim of this study was to evaluate whether subclinical thyroid disease is associated with impaired health-related quality of life and a more adverse cardiovascular disease risk profile.Design A community-based cross-sectional study.Setting and participants A total of 1423 non-healthcare-seeking women, aged 18-75 years were randomly recruited from the community via the electoral roll from April 2002 to August 2003.Main outcome measures These were the scores for the Short-Form 36 (SF-36), the Psychological General Well-being Index (PGWI), thyroid hormone levels, serum lipids and high sensitivity C-reactive protein (hsCRP). Subclinical hypothyroidism (SCH) and subclinical hyperthyroidism (SCHyper) were defined as serum TSH > 4.0 mIU/l and < 0.5 mIU/l, respectively, with a normal free thyroxine (free T4) level.Results Evaluable data were available for all participants. 10.7% of all women had an abnormal TSH value. The prevalence of a low TSH level by age group ranged from 1.2% to 6.4%, whereas the prevalence of an elevated TSH level ranged from 2.8% to 9.2% and increased with age (P = 0.002). There were no significant differences between women with SCH or SCHyper and age-matched controls for the total PGWI score or the Mental and Physical Component Scores of the SF-36. Women with SCH were no different from controls for serum lipids or hsCRP. Using linear regression, SCH vs. euthyroidism did not make an independent contribution to variation in either total cholesterol or triglycerides, with or without adjustment for age +/- age(2) +/- BMI.Conclusions Our data indicate that subclinical thyroid disease in women in the community is not associated with lower well-being or impaired health-related quality of life and SCH is not associated with increased serum markers of CVD risk.