New insights into neuromodulatory approaches for the treatment of pain
New insights into neuromodulatory approaches for the treatment of pain
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DOI：
10.1016/j.jpain.2007.11.003
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发表时间：
2008-03-01
期刊：
影响因子：
4
通讯作者：
Fregni, Felipe
中科院分区：
文献类型：
--
作者：
Jensen, Mark P.;Hakimian, Shahin;Fregni, Felipe
关于疼痛体验和大脑状态（通过脑电图或EEG测量）之间的联系，最近有两条证据被发现。首先，来自许多来源的研究表明，大脑脑电图活动和疼痛体验之间存在联系。具体来说，这项研究表明，疼痛的主观体验与较慢波（δ，θ和α）活动的相对较低幅度和较快波（β）活动的相对较高幅度相关。其次，最近对影响疼痛的皮质神经调节的干预措施的兴趣有所增加，包括行为治疗（如自我催眠训练和神经反馈）以及侵入性和非侵入性脑刺激。虽然通过EEG测量的疼痛和大脑活动之间的直接因果关系尚未建立，通过试图直接影响EEG节律在皮层水平上进行疼痛治疗的目标是一个有趣的possibility.Perspective：初步证据表明，尚未充分测试或证明的可能性，即慢性疼痛的经历与通过脑电图评估的皮层活动有关。支持这一假设将有重要意义的理解机制，一些疼痛治疗的基础，并为慢性疼痛管理开发新的创新治疗。(C)2008年，美国疼痛协会。
Two lines of evidence about the association between the experience of pain and brain state (measured via electroencephalogram or EEG) have recently come to light. First, research from a number of sources suggests a link between brain EEG activity and the experience of pain. Specifically, this research suggests that the subjective experience of pain is associated with relatively lower amplitudes of slower wave (delta, theta, and alpha) activity and relatively higher amplitudes of faster wave (beta) activity. Second, there has been a recent increase in interest in interventions that impact the cortical neuromodulation of pain, including behavioral treatments (such as self-hypnosis training and neurofeedback) and both invasive and noninvasive brain stimulation. Although a direct causal link between experience of pain and brain activity as measured by EEG has not been established, the targeting of pain treatment at a cortical level by trying to affect EEG rhythms directly is an intriguing possibility.Perspective: Preliminary evidence suggests the possibility, which has not yet adequately tested or proven, that the experience of chronic pain is linked to cortical activity as assessed via an electroencephalogram. Support for this hypothesis would have important implications for understanding the mechanisms that underlie a number of pain treatments, and for developing new innovative treatments for chronic pain management. (C) 2008 by the American Pain Society.