Optimizing probe design for an implantable perfusion and oxygenation sensor.
Optimizing probe design for an implantable perfusion and oxygenation sensor.
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DOI：
10.1364/boe.2.2096
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发表时间：
2011-08-01
影响因子：
3.4
通讯作者：
Coté GL
中科院分区：
文献类型：
--
作者：
Akl TJ;Long R;McShane MJ;Ericson MN;Wilson MA;Coté GL
在努力开发一种可植入的光学灌注和氧合传感器，基于多波长反射脉搏血氧饱和度，我们调查的影响，源-检测器分离和其他源-检测器的特性，以优化传感器的信号与背景比，使用蒙特卡罗（MC）基于模拟和体外体模研究。在点源的情况下，发现0.45至1.25 mm范围内的分离是最佳的。源的数值孔径（NA）对所收集的信号没有影响，而源空间分布的加宽引起最佳源-检测器分离的偏移。具体而言，对于4.5 mm的平光束和2.4 mm × 2.5 mm的光电探测器，发现当源和探测器彼此相邻时，性能最佳。这些建模结果得到证实，从体外实验中收集的数据与染料溶液灌注模拟不同氧合状态的血红蛋白的吸收特性的肝脏体模。
In an effort to develop an implantable optical perfusion and oxygenation sensor, based on multiwavelength reflectance pulse oximetry, we investigate the effect of source–detector separation and other source-detector characteristics to optimize the sensor’s signal to background ratio using Monte Carlo (MC) based simulations and in vitro phantom studies. Separations in the range 0.45 to 1.25 mm were found to be optimal in the case of a point source. The numerical aperture (NA) of the source had no effect on the collected signal while the widening of the source spatial profile caused a shift in the optimal source-detector separation. Specifically, for a 4.5 mm flat beam and a 2.4 mm × 2.5 mm photodetector, the optimal performance was found to be when the source and detector are adjacent to each other. These modeling results were confirmed by data collected from in vitro experiments on a liver phantom perfused with dye solutions mimicking the absorption properties of hemoglobin for different oxygenation states.