Reproducibility of pulmonary blood flow measurements by phase-contrast MRI using different 1.5 T MR scanners at two institutions.
Reproducibility of pulmonary blood flow measurements by phase-contrast MRI using different 1.5 T MR scanners at two institutions.
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DOI：
10.1177/2058460116684370
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发表时间：
2017-01
影响因子：
1.1
通讯作者：
Murayama S
中科院分区：
文献类型：
--
作者：
Iraha R;Tsuchiya N;Yamashiro T;Iwasawa T;Murayama S
磁共振成像（MRI）可以通过提供定量信息而有益于疾病的诊断。然而，当在多机构、多供应商的情况下存在数值阈值时，再现性可能是一个主要问题。在不同机构使用两台不同的MR扫描仪（1.5 T）在相同受试者中使用相位对比（PC）成像测量肺血流量，并检查测量结果的重现性。参与者为10名健康志愿者（5名男性;年龄范围，27-36岁）。测量结果包括平均和最大血流速度、平均血流量以及加速时间和体积（AT和AV），这些数据来自PC-MRI的时间-流量曲线。同时还计算了肺动脉中感兴趣区域的最大、最小和平均面积。为了计算定量变量的重现性，采用了类内相关系数（ICC）。当获得足够的ICC时，进行Bland-Altman分析以识别任何系统性偏倚。ICC的平均血流量和AV几乎是完美的（r = 0.82和0.80），并在平均和最大面积，和AT（r = 0.63，0.74和0.64，分别）是实质性的。然而，两种扫描仪之间的面积测量存在固定偏差。此外，AV具有比例偏倚。我们的研究结果表明，来自不同的MR扫描仪的PC-MRI的各种指标是有前途的肺血流评估的共同指标。预计肺动脉PC-MRI的研究和临床应用将扩展到多机构情况。
Magnetic resonance imaging (MRI) can be beneficial for diagnosis of disease by offering quantitative information. However, reproducibility can be a major problem when there is a numerical threshold in multi-institution, multi-vendor situations. To measure pulmonary blood flow with phase-contrast (PC) imaging using two different MR scanners (1.5 T) at different institutions in the same participants and to examine the reproducibility of the measurements. Participants were 10 healthy volunteers (5 men; age range, 27–36 years). The measurements included the mean and maximal blood velocities, the mean blood flow volume, and the acceleration time and volume (AT and AV), derived from the time-flow curve of the PC-MRI. Simultaneously obtained maximal, minimal, and mean areas from regions of interest set in the pulmonary artery were also calculated. In order to calculate the reproducibility of the quantitative variables, intra-class correlation coefficients (ICCs) were employed. When an adequate ICC was obtained, Bland–Altman analysis was conducted to identify any systematic bias. The ICCs were almost perfect for the mean blood flow volume and the AV (r = 0.82 and 0.80), and were substantial in the mean and maximal areas, and the AT (r = 0.63, 0.74, and 0.64, respectively). However, there was a fixed bias in the area measurement between the two scanners. Also, the AV had a proportional bias. Our results reveal that various indices derived from PC-MRI on different MR scanners are promising as common indices for pulmonary flow assessment. Research and clinical use of PC-MRI for the pulmonary artery is expected to extend to multi-institution situations.