Polyamines, DNA methylation and cell differentiation.
Polyamines, DNA methylation and cell differentiation.
复制标题
多胺、DNA 甲基化和细胞分化。
DOI：
10.1007/978-1-4684-5637-0_26
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发表时间：
1988
影响因子：
--
通讯作者：
Smith,SS
中科院分区：
文献类型：
--
作者：
Heby,O;Persson,L;Smith,SS
Cells that have become depleted of their putrescine and spermidine content, e. g. by treatment with 2-difluoromethyl-ornithine (DFMO), an enzyme-activated irreversible inhibitor of ornithine decarboxylase (Metcalf et al., 1978), grow slowly or not at all (Heby, 1981; Pegg, 1988). In addition to causing growth arrest, polyamine depletion has been found to induce or suppress cell differentiation (Heby et al., 1987). Teratocarci-noma stem cells belong to the category of cells that are induced to differentiate in response to putrescine and spermidine depletion (Heby et al., 1983; 1987; Schindler et al., 1983; Oredsson et al., 1985).
