Secondary structure of the cyclic moiety of the peptide hormone oxytocin and its deamino analog.
Secondary structure of the cyclic moiety of the peptide hormone oxytocin and its deamino analog.
复制标题
肽激素催产素及其脱氨基类似物的环状部分的二级结构。
DOI：
10.1073/pnas.66.1.111
复制
发表时间：
1970
影响因子：
11.1
通讯作者：
R. Walter
中科院分区：
文献类型：
--
作者：
D. Urry;M. Ohnishi;R. Walter
通过核磁共振波谱（220 MHz）测定了催产素和脱氨基催产素的循环部分的二级结构。在二甲亚砜-甲醇混合物中，催产素含有一个β -转，涉及到- l-酪氨酸- l-异亮氨酸- l-谷氨酰胺- l-天冬酰胺-的序列。脱氨基催产素，除了β -转外，还含有一个氢键，涉及酪氨酸残基的酰胺氢和天冬酰胺残基的肽羰基，导致环组分的反平行β -型构象。初步尝试将激素肽的构象特征与其生物活性联系起来。
The secondary structure of the cyclic moiety of oxytocin and deamino-oxytocin has been determined by nuclear magnetic resonance spectroscopy (220 MHz). Oxytocin, in a dimethylsulfoxide-methanol mixture, contains a beta-turn involving the sequence -L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-. Deamino-oxytocin, in addition to the beta-turn, contains a hydrogen bond involving the amide hydrogen of the tyrosine residue and the peptide carbonyl group of the asparagine residue, resulting in an antiparallel beta-type conformation for the ring component. An initial attempt has been made to relate conformational features of the hormonal peptides to their biological activity.