Effect of fluoride and selected cationic surfactants on caries in rodents.
Effect of fluoride and selected cationic surfactants on caries in rodents.
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氟化物和选定的阳离子表面活性剂对啮齿动物龋齿的影响。
DOI：
10.1159/000261062
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发表时间：
1987
期刊：
影响因子：
4.2
通讯作者：
Kent,R
中科院分区：
文献类型：
--
作者：
Tamura,T;Gron,P;Caslavska,V;Kent,R
Zonyl FSC是一种阳离子含氟表面活性剂，当以饮用水中0.1%的浓度施用于啮齿动物时，显著增强了F的防龋效果[Caslavska等人，1987年]。同样，局部应用中性200 ppm F（每周4次）30秒，对仓鼠的龋齿抑制率为13%，而应用含有0.2% Zonyl FSC的相同溶液则抑制率为40%[格隆等人，本文研究了Zonyl FSC和Lodyne S-106两种阳离子表面活性剂在0.2%浓度的饮水中对仓鼠的抑车作用。选择用于该研究的阳离子表面活性剂是Zonyl FSC（Du蓬特Co.，威尔明顿，特拉华州）和Lodyne S-106（Ciba-Geigy Co.，Ardsley，NY）。Zonyl FSC含有50%的活性成分，其为在25：25%异丙醇和PLO的溶剂中的氟烷基硫醚季铵甲基硫酸盐。
Zonyl FSC, a cationic fluorosurfactant, significantly enhanced the cariostatic ef fect of F when administered to rodents at 0.1% concentration in the drinking water [Caslavska et al., 1987]. Similarly, 30-second topical applications of neutral 200ppm F (4 times/week) caused a 13% caries inhibition in the hamster, while ap plication of the same solution with 0.2% Zonyl FSC caused a 40% inhibition [Gron et al., 1987], In the present work, the car iostatic effects of two cationic surfactants, Zonyl FSC and Lodyne S-106, were com pared when administered to hamsters in fluoridated drinking water at 0.2% con centration. The cationic surfactants se lected for this study were Zonyl FSC (Du Pont Co., Wilmington, Del.) and Lodyne S-106 (Ciba-Geigy Co., Ardsley, NY). Zonyl FSC contains 50% of active compo nents, which are fluoroalkylthioether qua ternary ammonium methylsulfates in a solvent of 25: 25% isopropanol and PLO.