Effects of Exogenous Carbon Monoxide Releasing Molecules on the Development of Zebrafish Embryos and Larvae.
Effects of Exogenous Carbon Monoxide Releasing Molecules on the Development of Zebrafish Embryos and Larvae.
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DOI：
10.3967/bes2016.059
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发表时间：
2016-06
期刊：
影响因子：
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通讯作者：
Jing E Song;J. Si;R. Zhou;Huapeng Liu;Z. Wang;L. Gan;Fang Gui;B. Liu;Hong Zhang
中科院分区：
文献类型：
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作者：
Jing E Song;J. Si;R. Zhou;Huapeng Liu;Z. Wang;L. Gan;Fang Gui;B. Liu;Hong Zhang
使用外源性一氧化碳释放分子（CORMs）为临床应用提供了希望；然而，CORMs在体内的潜在危害仍然知之甚少。研究了CORM-3在受精后4 ~ 144 h暴露于6.25 ~ 400 μmol/L浓度下的发育毒性。毒性终点包括死亡率、自发运动、心率、孵化率、畸形、体长和幼虫行为。当浓度超过50 μmol/L时，CORM-3会破坏斑马鱼幼体的发育进程，产生胚胎发育毒性。
The use of exogenous carbon monoxide releasing molecules (CORMs) provides promise for clinical application; however, the hazard potential of CORMs in vivo remains poorly understood. The developmental toxicity of CORM-3 was investigated by exposure to concentrations ranging from 6.25 to 400 μmol/L during 4-144 h post fertilization. Toxicity endpoints of mortality, spontaneous movement, heart rate, hatching rate, malformation, body length, and larval behavior were measured. CORM-3 disrupted the progression of zebrafish larval development at concentrations exceeding 50 μmol/L, resulting in embryonic developmental toxicity.