Lesions of 13q may occur independently of deletion of 16q in spindle cell pleomorphic lipomas
Lesions of 13q may occur independently of deletion of 16q in spindle cell pleomorphic lipomas
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DOI：
10.1046/j.1365-2559.1997.2450851.x
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发表时间：
1997-09-01
期刊：
影响因子：
6.4
通讯作者：
VandenBerghe, H
中科院分区：
文献类型：
--
作者：
DalCin, P;Sciot, R;VandenBerghe, H
目的：最近的多学科研究已经允许在脂肪瘤的临床和组织学亚型中定义称为梭形细胞和/或多形性脂肪瘤，可能与部分16号单体和13号染色体异常有关，为了更接近潜在的关键分子变化，进一步的多学科病理学和遗传学研究表明，确定哪些染色体异常在这些肿瘤的发展中是至关重要的。方法和结果：在一项正在进行的脂肪瘤肿瘤的多学科研究中，包括临床表现、形态学、组织化学和细胞遗传学，发现了两例梭形细胞脂肪瘤伴克隆性染色体改变，两例均涉及染色体13，而只有一例显示部分单体16。结论：部分单体16是梭形细胞脂肪瘤的特征性病变，通常与13号染色体异常有关。本报告证实了先前的单一观察结果，然而，13号病变可能独立于16号病变发生，这表明在这些非常相似的脂肪瘤中存在不同的潜在分子病变。
Aims: Very recent multidisciplinary investigations have allowed for the definition among lipomas of a clinical and histological subtype called spindle cell and/or pleomorphic lipoma, possibly associated with partial monosomy 16 and anomalies of chromosome 13, In order to get nearer to the underlying critical molecular changes further multidisciplinary pathological and genetic research is indicated, to identify which chromosome(s) anomalies are crucial in the development of these tumours.Methods ann results: In an ongoing multidisciplinary study of lipomatous tumours, including clinical findings, morphology, histochemistry and cytogenetics, two instances were found of spindle cell lipoma with clonal chromosome changes, In both cases chromosome 13 was involved, whereas only one showed a partial monosomy 16.Conclusions: Partial monosomy 16 is a characteristic lesion in spindle cell lipoma, usually associated with anomalies of chromosome 13, The present report confirming a previous single observation indicates, however, that lesions of 13 may occur independently from lesions of 16, suggesting different underlying molecular lesions in these otherwise very similar lipomas.