Comparison between conventional surgery and radiotherapy for FIGO stage I-II cervical carcinoma: A retrospective Japanese study
Comparison between conventional surgery and radiotherapy for FIGO stage I-II cervical carcinoma: A retrospective Japanese study
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DOI：
10.1016/j.ygyno.2005.03.017
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发表时间：
2005-06-01
影响因子：
4.7
通讯作者：
Taketani, Y
中科院分区：
文献类型：
--
作者：
Yamashita, H;Nakagawa, K;Taketani, Y
目的.比较传统手术与放射治疗（RT）治疗宫颈癌的疗效。材料与方法。回顾性分析了1991年6月至2004年5月间152例宫颈癌根治术患者，这些患者接受了手术或高剂量率腔内近距离放射治疗（HDR-ICBT），有或没有外部RT。中位随访时间为43.5个月（范围：1.0- 130.0个月）。中位年龄为53岁（范围：25 - 81岁）。IA期13例（9%），113期52例（34%），IIA期24例（16%），IIB期63例（41%）。常规手术组包括115例（76%）行子宫切除术和盆腔淋巴结清扫术的患者。其中72例（63%）接受了术后放疗。37例患者（24%）被分配到RT组。其中14例（38%）接受了放化疗。3例I期患者接受单纯ICBT治疗，未接受外照射。手术和RT的5年病因特异性生存率（CSS）分别为79.9%和82.3%;这两种治疗之间的差异无统计学意义（P = 0.8524）。对于I期或11期患者，两种治疗之间的生存率差异也无统计学意义（I期P = 0.8407，11期P = 0.6418）。这项回顾性研究表明，RT结果与传统手术的I-II期宫颈癌患者的生存兼容。(c)2005年爱思唯尔公司All rights reserved.
Purpose. To compare treatment outcome results of conventional surgery vs. radiotherapy (RT) for carcinoma of the uterine cervix.Materials and methods. A retrospective analysis was conducted of 152 patients with uterine cervical cancer radically treated with surgery or high dose-rate intracavitary brachytherapy (HDR-ICBT) with or without external RT from June 1991 to May 2004. The median follow-up time was 43.5 months (range, 1.0- 130.0 months). The median age was 53 years (range, 25 -81 years). There were 13 patients (9%) in stage IA, 52 (34%) in stage 113, 24 (16%) in stage IIA, and 63 (41%) in stage IIB. The conventional surgery group included 115 patients (76%) who underwent hysterectomy with pelvic lymph node dissection. Of these, 72 (63%) received postoperative radiotherapy. Thirty-seven patients (24%) were assigned to the RT group. Of these, 14 (38%) received chemoradiotherapy. Three patients with stage I received ICBT-alone without external beam irradiation.Results. The 5-year cause-specific survival (CSS) rates for surgery and RT were 79.9% and 82.3%, respectively; the difference between these two treatments was not statistically significant (P = 0.8524). The differences in the survival rates between the two treatments for each of the stage I or stage 11 patients were also not statistically significant (P = 0.8407 for stage I and P = 0.6418 for stage 11).Conclusions. This retrospective study suggests that RT results in compatible survival with conventional surgery for patients with stage I-II cervical carcinoma. (c) 2005 Elsevier Inc. All rights reserved.